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与杰勒德·埃文对话。

In conversation with Gerard Evan.

机构信息

FEBS Journal, Cambridge, UK.

Department of Biochemistry, University of Cambridge, UK.

出版信息

FEBS J. 2019 Dec;286(24):4824-4831. doi: 10.1111/febs.15121.

Abstract

Gerard Evan is Head of Department and Sir William Dunn Professor at the Department of Biochemistry, University of Cambridge, UK. Driven by his innate passion to understand how things work, Gerard has devoted much of his career to understanding the molecular basis of cancer, particularly the roles played by oncogenes such as Myc. His work has helped elucidate the complex role that this gene plays in cell proliferation and apoptosis, and paved new avenues for the treatment of aggressive cancers. In this interview, Gerard provides an overview of what is known about the role of Myc in normal and cancer cells and provides a persuasive argument for the application of 'impersonalised therapy' involving Myc inhibition as part of future chemotherapeutic drug regimes.

摘要

杰勒德·伊万(Gerard Evan)是英国剑桥大学生化系系主任和威廉·邓恩爵士教授。受理解事物运作方式的本能热情驱使,杰勒德(Gerard)将职业生涯的大部分时间都致力于了解癌症的分子基础,尤其是癌基因如 Myc 所起的作用。他的工作帮助阐明了该基因在细胞增殖和细胞凋亡中所起的复杂作用,并为治疗侵袭性癌症开辟了新途径。在这次采访中,杰勒德(Gerard)概述了 Myc 在正常细胞和癌细胞中的作用,并有力地论证了将 Myc 抑制作为未来化疗药物治疗方案的一部分的“非个性化治疗”的应用。

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