Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Peptomyc S.L., Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Methods Mol Biol. 2021;2318:1-11. doi: 10.1007/978-1-0716-1476-1_1.
The MYC transcription factor coordinates a wide range of intra- and extracellular processes associated with tissue proliferation and regeneration. While these processes are typically tightly regulated in physiological conditions, they become deregulated in cancer, where MYC is oncogenically activated.The last decade has seen MYC progress from a renowned undruggable target to a hot topic in the cancer therapy field, as proof emerged from mouse models that its inhibition constitutes an effective and broadly applicable approach to fight cancer. However, there are several aspects of MYC biology that still appear to be elusive and maintain the interest in further studying this intriguing protein. Since MYC's discovery, more than four decades ago, multiple strategies have been developed to study it, related to the many and varied facets of its biology. This new version of The Myc gene: Methods and Protocols provides valuable tips from key "inhabitants of the MYC world," which significantly increase the reach of our investigative tools to shed light on the mysteries still surrounding MYC.
MYC 转录因子协调与组织增殖和再生相关的广泛的细胞内和细胞外过程。虽然这些过程在生理条件下通常受到严格调节，但在癌症中它们会失调，此时 MYC 被致癌激活。在过去的十年中，MYC 已经从一个众所周知的不可成药的靶点发展成为癌症治疗领域的热门话题，因为来自小鼠模型的证据表明，抑制 MYC 构成了一种有效且广泛适用的抗癌方法。然而，MYC 生物学的几个方面似乎仍然难以捉摸，这仍然促使人们进一步研究这种引人入胜的蛋白质。自 40 多年前 MYC 被发现以来，已经开发出多种研究方法，这些方法与 MYC 生物学的许多不同方面有关。《Myc 基因：方法与方案》的新版本提供了来自“MYC 世界的关键居民”的宝贵提示，这些提示大大增加了我们研究工具的范围，有助于揭示仍然围绕 MYC 的谜团。
