腭皱襞发育的分子机制。

Molecular mechanisms in palatal rugae development.

作者信息

Trakanant Supaluk, Nihara Jun, Kawasaki Maiko, Meguro Fumiya, Yamada Akane, Kawasaki Katsushige, Saito Isao, Takeyasu Maeda, Ohazama Atsushi

机构信息

Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8514, Japan; Division of Oral Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8514, Japan.

Division of Oral Anatomy, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8514, Japan.

出版信息

J Oral Biosci. 2020 Mar;62(1):30-35. doi: 10.1016/j.job.2019.12.002. Epub 2019 Dec 17.

DOI:10.1016/j.job.2019.12.002

PMID:31862387

Abstract

BACKGROUND

Periodic patterning of iterative structures is diverse across the animal kingdom. Clarifying the molecular mechanisms involved in the formation of these structures helps to elucidate the genetic commonality of developmental processes, as organs with these structures are believed to share the same molecular mechanisms and fundamental processes. Palatal rugae are periodic corrugated structures on the hard palate and are conserved in all mammals. Although the numbers and patterns of the palatal rugae are species specific, they are consistent in each mammalian species, except humans.

HIGHLIGHT

Palatal rugae development is thus under strict genetic control in most mammals and is an excellent model to investigate the genetic commonality of developmental processes to form periodic patterning.

CONCLUSION

This review highlights the current understanding of the molecular mechanisms of palatal rugae development.

摘要

背景

迭代结构的周期性模式在动物界中多种多样。阐明这些结构形成所涉及的分子机制有助于阐明发育过程的遗传共性，因为具有这些结构的器官被认为共享相同的分子机制和基本过程。腭皱襞是硬腭上的周期性波纹状结构，在所有哺乳动物中都存在。尽管腭皱襞的数量和模式具有物种特异性，但在除人类以外的每个哺乳动物物种中都是一致的。