Zollinger H, Goldmann A
Orthopädische Universitätsklinik Balgrist, Zürich.
Orthopade. 1988 Sep;17(5):397-403.
Among the 105 patients treated in the orthopedic department of the Balgrist university hospital in Zurich for Paget's disease of bone, a total of 353 skeletal lesions have been recorded, sited mainly in the pelvic area, in the lower extremities and in the spine. The average age of these patients at diagnosis was 64 years. In 20% of them only one bone was affected, while in 80% the condition was polyostotic. One-third of the bone changes are asymptomatic and were discovered incidentally. Deformities of the tubular bones are the most frequent pathological finding, being observed in 33% of these patients, followed by joint damage resulting from the illness in 20%. In a total of 35 patients it has been necessary to correct deformities of the tubular bones or joint malpositions because of an inherent risk of fracture, or to perform internal fixation of pathological fractures. Great importance is laid on preoperative evaluation of the pain genesis, and if it cannot be adequately determined from the history calcitonin medication is tried out. The postoperative healing tendency for bones and soft tissues is good in the vast majority of patients; there is no delay in fracture healing even with the rather long period of perioperative medication.
在苏黎世巴尔格里斯特大学医院骨科接受治疗的105例骨佩吉特病患者中，共记录到353处骨骼病变，主要位于骨盆区域、下肢和脊柱。这些患者确诊时的平均年龄为64岁。其中20%的患者仅一处骨骼受累，而80%的患者病情为多骨型。三分之一的骨骼变化无症状，是偶然发现的。管状骨畸形是最常见的病理表现，在这些患者中占33%，其次是疾病导致的关节损伤，占20%。共有35例患者因存在骨折固有风险而需要纠正管状骨畸形或关节错位，或对病理性骨折进行内固定。术前对疼痛成因的评估非常重要，如果无法从病史中充分确定，则尝试使用降钙素药物。绝大多数患者术后骨骼和软组织的愈合趋势良好；即使围手术期用药时间较长，骨折愈合也没有延迟。
