烟酰胺核苷酸对猴肝丝氨酸羟甲基转移酶的调节作用
Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide.
作者信息
Ramesh K S, Rao N A
出版信息
Biochem J. 1978 Sep 15;174(3):1055-8. doi: 10.1042/bj1741055.
Abstract
The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.
摘要
在将猴肝丝氨酸羟甲基转移酶与NADH和NADPH预孵育后，四氢叶酸对该酶的正向同促结合作用消失。NAD⁺是负向异促效应物，而NADP⁺则无作用。首次报道的烟酰胺核苷酸对丝氨酸羟甲基转移酶的变构效应，有助于更好地理解叶酸辅酶代谢互变的调节机制。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine.S-腺苷甲硫氨酸对大鼠肝脏中亚甲基四氢叶酸还原酶的反馈抑制作用。
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