Calapkulu Murat, Sencar Muhammed Erkam, Sakiz Davut, Duger Hakan, Ozturk Unsal Ilknur, Ozbek Mustafa, Cakal Erman
Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Department of Endocrinology and Metabolism, Mardin State Hospital, Mardin, Turkey.
Endocrine. 2020 Apr;68(1):138-143. doi: 10.1007/s12020-019-02163-w. Epub 2019 Dec 21.
Subacute thyroiditis (SAT) is an acute inflammatory disease of the thyroid. Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) values determined from peripheral blood, are accepted as available and practical indicators of systemic inflammation. The purpose of this study was to evaluate the value of hematological parameters in the diagnosis and prognosis of subacute thyroiditis patients.
This retrospective study included 306 SAT patients and 102 healthy control subjects. Retrospective analyses were made of age, gender, complete blood counts, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), thyroid function tests, NLR, PLR, and thyroid volume of the patients and the results were compared with the control group.
The mean follow-up time of patients was 29.5 ± 14 months. The ESR, CRP, white blood cell (WBC) count, neutrophil count, hemoglobin, platelet counts, NLR, and PLR were significantly higher in the SAT patients. MPV and lymphocyte count were significantly lower in the SAT patients. The rates of recurrence and permanent hypothyroidism were 15.4% and 9.8%, respectively. The values of ESR, CRP, NLR, PLR, and MPV at the time of diagnosis were not determined to have any effect on recurrence or the development of permanent hypothyroidism.
The results of this study showed higher PLR and NLR values in SAT patients compared with healthy control subjects, and a lower MPV value. These findings demonstrate that the assessment of hematological parameters in conjunction with radiological and clinical findings will assist in establishing an accurate diagnosis, especially in complicated SAT cases.
亚急性甲状腺炎（SAT）是一种甲状腺的急性炎症性疾病。外周血中测定的平均血小板体积（MPV）、中性粒细胞与淋巴细胞比值（NLR）以及血小板与淋巴细胞比值（PLR）被认为是全身性炎症的有效且实用的指标。本研究的目的是评估血液学参数在亚急性甲状腺炎患者诊断和预后中的价值。
这项回顾性研究纳入了306例亚急性甲状腺炎患者和102例健康对照者。对患者的年龄、性别、全血细胞计数、C反应蛋白（CRP）、红细胞沉降率（ESR）、甲状腺功能检查、NLR、PLR以及甲状腺体积进行回顾性分析，并将结果与对照组进行比较。
患者的平均随访时间为29.5±14个月。亚急性甲状腺炎患者的ESR、CRP、白细胞（WBC）计数、中性粒细胞计数、血红蛋白、血小板计数、NLR和PLR显著更高。亚急性甲状腺炎患者的MPV和淋巴细胞计数显著更低。复发率和永久性甲状腺功能减退率分别为15.4%和9.8%。诊断时的ESR、CRP、NLR、PLR和MPV值未被确定对复发或永久性甲状腺功能减退的发生有任何影响。
本研究结果显示，与健康对照者相比，亚急性甲状腺炎患者的PLR和NLR值更高，MPV值更低。这些发现表明，结合放射学和临床发现评估血液学参数将有助于准确诊断，尤其是在复杂的亚急性甲状腺炎病例中。
