Kovačević Milena, Vezmar Kovačević Sandra, Radovanović Slavica, Stevanović Predrag, Miljković Branislava
Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000, Belgrade, Serbia.
University Clinical Hospital Center Bezanijska Kosa, Faculty of Medicine, University of Belgrade, Bezanijska Kosa bb, 11080, Belgrade, Serbia.
Int J Clin Pharm. 2020 Feb;42(1):150-157. doi: 10.1007/s11096-019-00951-y. Epub 2019 Dec 21.
Background Drug-drug interactions represent one of the causes of adverse therapy outcomes through deteriorated efficacy or safety. However, the true extent of harm related to drug-drug interactions is not well established due to a lack of recognition and understanding. Objective The aim of this study was to investigate the association of potential drug-drug interactions with patients variables recorded at admission. Setting A cross-sectional correlation study was performed on the Cardiology ward of the University Clinical Hospital Center in Belgrade, Serbia. Method Data were retrospectively obtained from medical records and LexiInteract was used as the screening tool for potential drug-drug interactions. Main outcome measure Clinical and laboratory parameters recorded at the patients admission. Results A total of 351 patient records entered the analysis, with the mean age of 70 ± 10 years. The prevalence of potentially relevant drug-drug interactions was 61% (N = 213). After controlling for patient characteristics, nine potential drug-drug interactions were significantly associated with laboratory values outside the range and five potential drug-drug interactions with inadequate clinical parameter values. Potential drug-drug interactions were associated with abnormalities in blood count, metabolic parameters, electrolyte imbalance and renal function parameters. Association with inadequate control of systolic, diastolic blood pressure, as well as heart rhythm was also shown. Conclusion Drug-drug interactions were associated with patients clinical and laboratory findings. Our findings may assist in the identification of patients with increased likelihood of suboptimal therapy outcomes. Generating evidence through post-marketing drug-drug interactions research would lead to improvement in clinical decision-support systems, increased effectiveness and utilization in everyday clinical practice.
背景 药物相互作用是导致治疗效果不佳或安全性下降等不良治疗结果的原因之一。然而，由于缺乏认识和理解，与药物相互作用相关的真正危害程度尚未完全明确。目的 本研究旨在调查潜在药物相互作用与入院时记录的患者变量之间的关联。设置 在塞尔维亚贝尔格莱德大学临床医院中心的心脏病科进行了一项横断面相关性研究。方法 从病历中回顾性获取数据，并使用LexiInteract作为潜在药物相互作用的筛查工具。主要观察指标 患者入院时记录的临床和实验室参数。结果 共有351份患者记录纳入分析，平均年龄为70±10岁。潜在相关药物相互作用的发生率为61%（N = 213）。在控制患者特征后，9种潜在药物相互作用与超出范围的实验室值显著相关，5种潜在药物相互作用与临床参数值不充分相关。潜在药物相互作用与血细胞计数异常、代谢参数、电解质失衡和肾功能参数有关。还显示与收缩压、舒张压以及心律控制不佳有关。结论 药物相互作用与患者的临床和实验室检查结果相关。我们的研究结果可能有助于识别治疗效果欠佳可能性增加的患者。通过上市后药物相互作用研究生成证据将导致临床决策支持系统的改进，提高日常临床实践中的有效性和利用率。
