靶向治疗时代超越手术观点：脊柱转移瘤治疗前脊柱外科医生应了解的内容。
The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases.
机构信息
Dipartimento di Neuroscienze, Neurosurgery, Universita degli Studi di Torino, Torino, Italy.
Dipartimento di Scienze Mediche, Pathology, Universita degli Studi di Torino, Torino, Italy.
出版信息
Cancer Control. 2019 Jan-Dec;26(1):1073274819870549. doi: 10.1177/1073274819870549.
Abstract
In the last few years, the treatment of spinal metastases has significantly changed. This is due to the advancements in surgical technique, radiotherapy, and chemotherapy which have enriched the multidisciplinary management. Above all, the field of molecular biology of tumors is in continuous and prosperous evolution. In this review, the molecular markers and new approaches that have radically modified the chemotherapeutic strategy of the most common metastatic neoplasms will be examined together with clinical and surgical implications. The experience and skills of several different medical professionals are mandatory: an interdisciplinary oncology team represents the winning strategy in the treatment of patients with spinal metastases.
摘要
在过去的几年中，脊柱转移瘤的治疗发生了显著变化。这是由于手术技术、放疗和化疗的进步丰富了多学科管理。最重要的是，肿瘤分子生物学领域正在不断蓬勃发展。在这篇综述中，我们将探讨共同改变最常见转移性肿瘤的化疗策略的分子标志物和新方法，并探讨其临床和手术意义。需要有多位不同医学专业人员的经验和技能：肿瘤多学科团队是治疗脊柱转移瘤患者的制胜策略。
相似文献
1
The Targeted Therapies Era Beyond the Surgical Point of View: What Spine Surgeons Should Know Before Approaching Spinal Metastases.
Cancer Control. 2019 Jan-Dec;26(1):1073274819870549. doi: 10.1177/1073274819870549.
2
New therapeutics in spine metastases.
Expert Rev Neurother. 2005 Nov;5(6):831-40. doi: 10.1586/14737175.5.6.831.
3
Surgical results of metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC): analysis of functional outcome, survival time, and complication.
Spine J. 2016 Mar;16(3):322-8. doi: 10.1016/j.spinee.2015.11.005. Epub 2015 Nov 14.
4
The Effect of Introducing the Spinal Instability Neoplastic Score in Routine Clinical Practice for Patients With Spinal Metastases.
Oncologist. 2016 Jan;21(1):95-101. doi: 10.1634/theoncologist.2015-0266. Epub 2015 Dec 14.
5
[Role of surgery in the management of vertebral metastases. General revue].
Cancer Radiother. 2016 Oct;20(6-7):484-92. doi: 10.1016/j.canrad.2016.07.086. Epub 2016 Sep 7.
6
Surgical strategy for spinal metastases.
Spine (Phila Pa 1976). 2001 Feb 1;26(3):298-306. doi: 10.1097/00007632-200102010-00016.
7
Treatment of spine metastases in cancer: a review.
J Int Med Res. 2020 Apr;48(4):300060519888107. doi: 10.1177/0300060519888107. Epub 2019 Dec 26.
8
Surgical Treatment in Patients with Spinal Tumors - Differences in Surgical Strategies and Malignancy-Associated Problems. An Analysis of 474 Patients.
Ortop Traumatol Rehabil. 2015 May-Jun;17(3):229-40. doi: 10.5604/15093492.1162422.
9
Current paradigms for metastatic spinal disease: an evidence-based review.
Ann Surg Oncol. 2014 Jan;21(1):248-62. doi: 10.1245/s10434-013-3324-8. Epub 2013 Oct 22.
10
Evolution in treatment strategy for metastatic spine disease: Presently evolving modalities.
Eur J Surg Oncol. 2017 Sep;43(9):1784-1801. doi: 10.1016/j.ejso.2017.05.006. Epub 2017 May 17.
引用本文的文献
1
Overview of Molecular Prognostication for Common Solid Tumor Histologies - What the Surgeon Should Know.
Global Spine J. 2025 Jan;15(1_suppl):6S-15S. doi: 10.1177/21925682241250327.
2
A Multidisciplinary Update on Treatment Modalities for Metastatic Spinal Tumors with a Surgical Emphasis: A Literature Review and Evaluation of the Role of Artificial Intelligence.
Cancers (Basel). 2024 Aug 8;16(16):2800. doi: 10.3390/cancers16162800.
3
Carbon Fiber-Reinforced Polyetheretherketone Spinal Implants for Treatment of Spinal Tumors: Perceived Advantages and Limitations.
Neurospine. 2023 Mar;20(1):317-326. doi: 10.14245/ns.2244920.460. Epub 2023 Mar 31.
4
Spinal Metastases and the Evolving Role of Molecular Targeted Therapy, Chemotherapy, and Immunotherapy.
Neurospine. 2022 Dec;19(4):978-993. doi: 10.14245/ns.2244290.145. Epub 2022 Dec 31.
5
Long-Term Clinical Outcomes of Patients with Colorectal Cancer with Metastatic Epidural Spinal Cord Compression Treated with Hybrid Therapy (Surgery Followed by Stereotactic Body Radiation Therapy).
World Neurosurg. 2023 Jan;169:e89-e95. doi: 10.1016/j.wneu.2022.10.053. Epub 2022 Oct 19.
6
Prolonged durability of extensive contiguous spinal metastasis stabilization in non-small cell lung cancer patients receiving targeted therapy: two case reports and a literature review.
J Int Med Res. 2022 Jun;50(6):3000605221105003. doi: 10.1177/03000605221105003.
7
Attitudes and trends in the use of radiolucent spinal implants: A survey of the North American Spine Society section of spinal oncology.
N Am Spine Soc J. 2022 Feb 23;10:100105. doi: 10.1016/j.xnsj.2022.100105. eCollection 2022 Jun.
8
Craniovertebral junction chordomas: Case series and strategies to overcome the surgical challenge.
J Craniovertebr Junction Spine. 2021 Oct-Dec;12(4):420-431. doi: 10.4103/jcvjs.jcvjs_87_21. Epub 2021 Dec 11.
9
Letter to the Editor Regarding "COVID-19: A Time Like No Other in (the Department of) Neurological Surgery". Should We Broaden Surgical Indications to Preserve the Standard of Care in Spinal Metastases?
World Neurosurg. 2021 Jul;151:303-304. doi: 10.1016/j.wneu.2021.03.154.
10
Solitary late spinal metastasis from apocrine salivary duct carcinoma: Case report.
Surg Neurol Int. 2021 Mar 30;12:122. doi: 10.25259/SNI_903_2020. eCollection 2021.
本文引用的文献
1
Immunotherapy in myeloma: how far have we come?
Ther Adv Hematol. 2019 Jan 18;10:2040620718822660. doi: 10.1177/2040620718822660. eCollection 2019.
2
Advances in the Treatment of Metastatic Renal Cell Carcinoma.
Cancer Treat Res. 2018;175:127-137. doi: 10.1007/978-3-319-93339-9_6.
3
New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors.
Int J Mol Sci. 2018 Aug 28;19(9):2545. doi: 10.3390/ijms19092545.
4
Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects.
F1000Res. 2018 Aug 2;7. doi: 10.12688/f1000research.14499.1. eCollection 2018.
5
Metastatic Melanoma: Recent Therapeutic Progress and Future Perspectives.
Drugs. 2018 Aug;78(12):1197-1209. doi: 10.1007/s40265-018-0945-z.
6
Emerging therapies in advanced hepatocellular carcinoma.
Exp Hematol Oncol. 2018 Aug 3;7:17. doi: 10.1186/s40164-018-0109-6. eCollection 2018.
7
Targeted therapy for metastatic colorectal cancer.
Expert Rev Anticancer Ther. 2018 Oct;18(10):991-1006. doi: 10.1080/14737140.2018.1502664. Epub 2018 Aug 3.
8
Chimeric Antigen Receptor Therapy.
N Engl J Med. 2018 Jul 5;379(1):64-73. doi: 10.1056/NEJMra1706169.
9
Recent Advances in the Treatment of Breast Cancer.
Front Oncol. 2018 Jun 14;8:227. doi: 10.3389/fonc.2018.00227. eCollection 2018.
10
Chimeric antigen receptor-engineered T-cell therapy for liver cancer.
Hepatobiliary Pancreat Dis Int. 2018 Aug;17(4):301-309. doi: 10.1016/j.hbpd.2018.05.005. Epub 2018 May 24.
Zotero 插件