Bhaskaruni Sandeep V H S, Maddila Suresh, van Zyl Werner E, Jonnalagadda Sreekantha B
School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa.
ACS Omega. 2019 Dec 5;4(25):21187-21196. doi: 10.1021/acsomega.9b02608. eCollection 2019 Dec 17.
Nickel oxide loaded on zirconia (NiO/ZrO) as an expedient catalyst is reported for the synthesis of 18 unsymmetrical 1,4-dihydropyridine derivatives. The Lewis acidic nature of the catalyst proved an excellent choice for the one-pot, four-component fusion reaction with excellent yields of 89-98% and a completion time of 20-45 min. Mechanistic studies show that enamine and imine functionalities are the two possible pathways for the formation of 1,4-dihydropyridines with high selectivity. Crystal structures of two novel compounds (, ) were reported. The catalyst demonstrated reusability up to six cycles. The reaction at room temperature and ethanol as a solvent make this protocol green and economical.
据报道，负载在氧化锆上的氧化镍（NiO/ZrO）作为一种便捷催化剂，用于合成18种不对称的1,4-二氢吡啶衍生物。该催化剂的路易斯酸性性质被证明是一锅四组分融合反应的极佳选择，产率高达89-98%，反应完成时间为20-45分钟。机理研究表明，烯胺和亚胺官能团是高选择性形成1,4-二氢吡啶的两种可能途径。报道了两种新型化合物（，）的晶体结构。该催化剂可重复使用多达六个循环。在室温下以乙醇为溶剂进行反应，使该方法既绿色又经济。
Zotero 插件
