Khan Shahid Ali, Khan Sher Bahadar, Asiri Abdullah M, Ahmad Ikram
Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, Jeddah, Saudi Arabia.
Nanoscale Res Lett. 2016 Dec;11(1):345. doi: 10.1186/s11671-016-1525-3. Epub 2016 Jul 26.
Coumarins play an important role in drug development with diverse biological applications. Herein, we present the synthesis of coumarin through Pechmann reaction by using zirconia-based heterogeneous catalysts (ZrO2-TiO2, ZrO2-ZnO, and ZrO2/cellulose) in a solvent-free condition at room temperature. ZrO2-TiO2, ZrO2-ZnO, and ZrO2/cellulose were identified through spectroscopic techniques such as FESEM, X-ray, EDS, XPS, and FT-IR. ZrO2-TiO2 showed the best catalytic performance while ZrO2/cellulose was inactive. The kinetic parameters were observed in a solvent-free condition as well as in toluene and ethanol. The temperature effect was extensively studied which revealed that increasing the temperature will increase the rate of reaction. The rate of reaction in a solvent-free condition, ethanol, and toluene were 1.7 × 10(-3), 1.7 × 10(-2), and 5.6 × 10(-3) g mol(-1) min(-1), respectively.
香豆素在具有多种生物应用的药物开发中发挥着重要作用。在此，我们展示了在室温无溶剂条件下，通过使用基于氧化锆的多相催化剂（ZrO2-TiO2、ZrO2-ZnO和ZrO2/纤维素），经由Pechmann反应合成香豆素。通过诸如场发射扫描电子显微镜（FESEM）、X射线、能谱仪（EDS）、X射线光电子能谱（XPS）和傅里叶变换红外光谱（FT-IR）等光谱技术对ZrO2-TiO2、ZrO2-ZnO和ZrO2/纤维素进行了鉴定。ZrO2-TiO2表现出最佳的催化性能，而ZrO2/纤维素没有活性。在无溶剂条件以及甲苯和乙醇中观察了动力学参数。对温度效应进行了广泛研究，结果表明升高温度会提高反应速率。在无溶剂条件、乙醇和甲苯中的反应速率分别为1.7×10(-3)、1.7×10(-2)和5.6×10(-3) g mol(-1) min(-1)。
