Zhang Lei, Li Chao-Ding, Shen Jin-Hu, Yang Liu-Zhong, Wang Jian-Wei, Zhang Zhen, Luo Zhong-Wei, Cheng Fei
Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou 221000, Jiangsu, China;
Zhongguo Gu Shang. 2019 Dec 25;32(12):1144-1147. doi: 10.3969/j.issn.1003-0034.2019.12.015.
To explore the clinical effect of Qufu Shengji ointment(QFSJO) in promoting the wound healing after trauma.
From January 2014 to June 2018, 60 patients with soft tissue injury, skin defect and wound infection caused by violent trauma were admitted, including 32 males and 28 females, aged from 18 to 65 years, with an average age of 41.3 years. Among them, 30 patients were treated with QFSJO (QFSJO group) and 30 patients were treated with normal saline iodophor (control group). The reduction rate of wound area, the days of decayed flesh, the time of new epithelium and the recovery rate of 28 days after dressing change were compared between the two groups.
In the QFSJO group, after using large dose of QFSJO, the pus of the wound increased, the granulation grew, and the new epithelium appeared on the edge of the wound, showing a rapid healing phenomenon. The wound healing rate of QFSJO group was higher than that of the control group at all time points, and the time of decaying flesh and new epithelium appeared in QFSJO group was earlier than that of the control group. The recovery rate of QFSJO group was significantly higher than that of the control group(<0.05). All the patients were followed up, and the duration ranged form 6 to 12 months, with an average of 9.4 months. The exposed areas of bone and teadon were covered well. The vital signs of the two groups were stable and no adverse reactions occurred.
QFSJO can promote the growth of granulation tissue, promote the production of new skin, and accelerate the healing of infectious wound after trauma.
探讨祛腐生肌膏促进创伤后伤口愈合的临床效果。
选取2014年1月至2018年6月因暴力创伤导致软组织损伤、皮肤缺损及伤口感染的患者60例，其中男32例，女28例，年龄18～65岁，平均年龄41.3岁。将患者分为两组，每组30例。祛腐生肌膏组30例患者采用祛腐生肌膏治疗，对照组30例患者采用生理盐水碘伏治疗。比较两组患者换药后伤口面积缩小率、腐肉脱落天数、新上皮出现时间及28天愈合率。
祛腐生肌膏组大剂量使用祛腐生肌膏后，伤口脓液增多，肉芽生长，伤口边缘出现新上皮，呈现快速愈合现象。祛腐生肌膏组各时间点伤口愈合率均高于对照组，祛腐生肌膏组腐肉脱落及新上皮出现时间均早于对照组。祛腐生肌膏组愈合率显著高于对照组（P<0.05）。所有患者均获随访，随访时间6～12个月，平均9.4个月。骨与肌腱外露部位覆盖良好。两组患者生命体征平稳，均未出现不良反应。
祛腐生肌膏能促进肉芽组织生长，促进新皮肤生成，加速创伤后感染伤口的愈合。
