炎症性肠病患儿的乳糖吸收不良与乳糖不耐受

Lactose Malabsorption and Lactose Intolerance in Children with Inflammatory Bowel Diseases.

作者信息

Jasielska Martyna, Grzybowska-Chlebowczyk Urszula

机构信息

Department of Pediatrics, Medical University of Silesia, Katowice, Poland.

出版信息

Gastroenterol Res Pract. 2019 Dec 1;2019:2507242. doi: 10.1155/2019/2507242. eCollection 2019.

DOI:10.1155/2019/2507242

PMID:31871445

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6913261/

Abstract

BACKGROUND

Insufficient vitamin D and calcium intake associated with the restricted intake of milk and dairy products can lead to poor health outcomes like malnutrition and abnormal bone mineralization. The aim of the study was to estimate the prevalence of primary and secondary lactose intolerance in children with IBD.

METHODS

The study included 107 patients (mean age 14.07 ± 3.58 years; 46.7% boys) which includes 43 patients with Crohn's disease (CD), 31 with ulcerative colitis (UC), and 33 children with functional abdominal pain (AP-FGID). We analysed the result of the hydrogen breath test with lactose loading, two single nucleotide polymorphisms of the gene (LCT-13910CC and LCT-22018GG). The results were analysed with MedCalc Statistical Software.

RESULTS

Adult-type hypolactasia (ATH) was found in 31% of patients with IBD and 42.4% of AP-FGID ( = 0.2). Lactose malabsorption (LM) was found in 27.9% of patients with CD, in 22.6% with UC, and in 24.2% with AP-FGID ( = 0.8). Lactose intolerance (LI) was diagnosed in a similar percentage of patients in each group ( = 0.9). Secondary LI in IBD patients does not depend on the location, duration, and activity of the disease and the number of relapses ( > 0.05). The median time of lactose-free diet in CD was 10 months and in CU 24 months.

CONCLUSIONS

The incidence of LI, LM, and ATH does not differ among children with IBD from the population.

摘要

背景

与牛奶和乳制品摄入受限相关的维生素D和钙摄入不足会导致营养不良和骨矿化异常等不良健康后果。本研究的目的是评估炎症性肠病（IBD）患儿原发性和继发性乳糖不耐受的患病率。

方法

本研究纳入107例患者（平均年龄14.07±3.58岁；46.7%为男孩），其中包括43例克罗恩病（CD）患者、31例溃疡性结肠炎（UC）患者和33例功能性腹痛（AP - FGID）儿童。我们分析了乳糖负荷氢呼气试验的结果、基因的两个单核苷酸多态性（LCT - 13910CC和LCT - 22018GG）。结果用MedCalc统计软件进行分析。

结果

在31%的IBD患者和42.4%的AP - FGID患者中发现成人型低乳糖酶症（ATH）（P = 0.2）。在27.9%的CD患者、22.6%的UC患者和24.2%的AP - FGID患者中发现乳糖吸收不良（LM）（P = 0.8）。每组中诊断为乳糖不耐受（LI）的患者比例相似（P = 0.9）。IBD患者的继发性LI不取决于疾病的部位、持续时间、活动度和复发次数（P>0.05）。CD患者无乳糖饮食的中位时间为10个月，UC患者为24个月。