中国孕妇在同一平台上血清促甲状腺激素的多样化上界参考范围。
The Diverse Upper Reference Limits of Serum Thyroid-Stimulating Hormone on the Same Platform for Pregnant Women in China.
机构信息
Department of Clinical Laboratory, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital.
Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
出版信息
Lab Med. 2020 Jul 8;51(4):416-422. doi: 10.1093/labmed/lmz089.
OBJECTIVE
To describe the diverse upper reference limits of serum thyroid stimulating hormone on the same platform for pregnant women in China.
METHODS
The trimester-specific and population-specific TSH reference intervals for pregnant women were established, and then 5 reference intervals on the same platform in China were compared with the reference intervals derived from the present study and the manufacturer.
RESULTS
The most striking difference in the upper reference limits of TSH among 5 reference intervals on the same platform was shown at the first trimester of pregnancy. The calculated regional prevalence rates of subclinical thyroid diseases varied using the data derived from 30,771 pregnant women who visited the largest obstetric center in our district from 2008 to 2018.
CONCLUSION
We reported differences among 7 reference intervals of TSH on the same platform and showed the changing population factors significantly affected them.
目的
描述中国孕妇在同一平台上血清促甲状腺激素（TSH）的多种上参考限。
方法
建立了妊娠特异性和人群特异性 TSH 参考区间，然后比较了中国的 5 个参考区间与本研究和制造商得出的参考区间。
结果
同一平台上的 5 个 TSH 上参考限中，妊娠早期的差异最为显著。使用 2008 年至 2018 年期间访问我们地区最大的妇产科中心的 30771 名孕妇的数据计算，不同地区亚临床甲状腺疾病的患病率存在差异。
结论
我们报告了同一平台上 7 个 TSH 参考区间的差异，并表明不断变化的人口因素对它们有显著影响。
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