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门诊护理营养干预以预康复计划手术的营养不良患者:一项多中心、集群随机试点研究。

An outpatient nursing nutritional intervention to prehabilitate undernourished patients planned for surgery: A multicentre, cluster-randomised pilot study.

机构信息

Department of Nutrition, Physical Activity and Sports, Department of Surgery, Gelderse Vallei Hospital, Ede, the Netherlands; Radboud University Medical Centre, Radboud Institute for Health Sciences, IQ Healthcare, Nijmegen, the Netherlands.

Department of Gastroenterology and Hepatology, Gelderse Vallei Hospital, Ede, the Netherlands; Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands.

出版信息

Clin Nutr. 2020 Aug;39(8):2420-2427. doi: 10.1016/j.clnu.2019.11.038. Epub 2019 Dec 2.


DOI:10.1016/j.clnu.2019.11.038
PMID:31879076
Abstract

BACKGROUND & AIMS: To improve the nutritional status of surgical patients before hospital admission, an Outpatient Nursing Nutritional Intervention (ONNI) was developed. The ONNI comprehends five components: determining causes of undernutrition, performing a nutritional care plan including tailored and general advice, self-monitoring of nutritional intake and eating patterns, counselling and encouragement, and conducting a follow-up telephone call to discuss improvements in nutritional behaviour. Here, we evaluate the feasibility and effectiveness of the ONNI. METHODS: In a multi-centred, cluster-randomised pilot study, nurses from outpatient clinics were randomly allocated to usual care (UC) or the ONNI. Patients planned for elective surgery were included if they were at increased risk for undernutrition based on the Malnutrition Universal Screening Tool (MUST) and hospital admission was not planned within seven days. Feasibility outcomes included participation rate, extent of intervention delivery, and patient satisfaction. Nutritional intake was monitored for two days before admission. Body weight, BMI and MUST scores at hospital admission were compared to measurements from the outpatient clinic visit. Data were analysed on an intention-to-treat basis by researchers who were blinded for patients and caregivers. RESULTS: Forty-eight patients enrolled the feasibility phase. Participation rate was 72%. Nurses delivered all intervention components adequately in the end of the implementation period. Finally, 152 patients (IG: n = 66, 43%) participated in the study. A significant difference in mean energy intake (870 kcal/d, 95%CI:630-1109 p < 0.000) and mean protein intake (34.1 g/d, 95%CI: 25.0-43.2; p < 0.000) was observed in favour of the IG. Nutritional energy requirements were achieved in 74% (n = 46) of the IG and in 17% (n = 13) of the UC group (p < 0.000), and protein requirements were achieved in 52% (n = 32) of the IG, compared to 8% (n = 6) of the UC group (p < 0.000). Body weight, BMI and MUST scores did not change in either group. CONCLUSIONS: The ONNI is a feasible and effective intervention tool for nurses at outpatient clinics. Patients in the IG had more nutritional intake and fulfilled nutritional requirements significantly more often than patients receiving UC. Further research is required to determine the optimal pre-operative timing of nutritional support and to measure its effect on other patients groups. CLINICAL TRIAL REGISTRATION: The study protocol was registered at the ClinicalTrial.gov website with the following identifier: NCT02440165.

摘要

背景与目的:为改善住院患者术前的营养状况,开发了门诊护理营养干预(ONNI)。ONNI 包括五个部分:确定营养不良的原因,制定包括量身定制和一般建议的营养护理计划,自我监测营养摄入和饮食模式,咨询和鼓励,并进行后续电话讨论改善营养行为。在这里,我们评估 ONNI 的可行性和有效性。

方法:在一项多中心、集群随机试点研究中,门诊护士被随机分配到常规护理(UC)或 ONNI。如果基于营养不良通用筛查工具(MUST)患者有营养不良风险且计划住院时间不超过 7 天,则计划接受择期手术的患者将被纳入。可行性结果包括参与率、干预措施的实施程度和患者满意度。在入院前监测两天的营养摄入量。入院时的体重、BMI 和 MUST 评分与门诊就诊时的测量值进行比较。研究人员对患者和护理人员进行盲法分析,采用意向治疗进行数据分析。

结果:48 名患者参与了可行性阶段。参与率为 72%。护士在实施期末充分提供了所有干预措施。最后,共有 152 名患者(IG:n=66,43%)参与了研究。IG 组的平均能量摄入量(870kcal/d,95%CI:630-1109,p<0.000)和平均蛋白质摄入量(34.1g/d,95%CI:25.0-43.2;p<0.000)显著增加。IG 组 74%(n=46)满足能量需求,UC 组 17%(n=13)满足(p<0.000),IG 组 52%(n=32)满足蛋白质需求,UC 组 8%(n=6)满足(p<0.000)。两组体重、BMI 和 MUST 评分均无变化。

结论:ONNI 是门诊护士一种可行且有效的干预工具。IG 组患者的营养摄入更多,满足营养需求的比例明显高于接受 UC 组的患者。需要进一步研究确定最佳术前营养支持时机,并测量其对其他患者群体的影响。

临床试验注册:研究方案在 ClinicalTrial.gov 网站上注册,标识符为:NCT02440165。

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