Hantoushzadeh Sedigheh, Borna Sedigheh, Khazardoost Soghra, Jafari Asieh, Talebian Marzieh
Maternal Fetal and Neonatal Research Center, Family Health Institute, Tehran University of Medical Sciences, Tehran, Iran.
Int J Prev Med. 2019 Nov 28;10:203. doi: 10.4103/ijpvm.IJPVM_414_17. eCollection 2019.
To compare the umbilical cord diameter (UCD) at early second trimester (at 17-19 weeks of gestation) in trisomy 21 and normal fetuses and determined value of measuring UCD in screening trisomy 21.
This was a case-control study. The UCD was measured in 39 fetuses with trisomy 21 (documented by chorionic villus sampling or amniocentesis) and 39 fetuses in control group at 17-19 weeks of gestation. The control groups were low-risk fetuses for aneuploidy in routine screening and were shown not to have aneuploidy after birth.
Mean of UCD in fetuses with trisomy 21 was lower than normal fetuses, but there were no significant differences between them (7.48 ± 0.99 mm vs. 7.66 ± 0.91 mm; = 0.41). Mean of UCD had no significant difference between other maternal variable, for example, body mass index and obstetric history. Mean of UCD among mothers who had previous cesarean section was significantly lower than without it (7.21 ± 0.97 vs. 7.71 ± 0.97; = 0.03).
At 17-19 weeks of gestation, the UCD of fetuses with trisomy 21 is thinner than normal, but the importance of this difference is too small for using this measurement in screening.
比较孕中期早期（妊娠17 - 19周）21 -三体胎儿与正常胎儿的脐带直径（UCD），并确定测量UCD在筛查21 -三体中的价值。
这是一项病例对照研究。在39例21 -三体胎儿（经绒毛取样或羊膜腔穿刺确诊）和39例对照组胎儿妊娠17 - 19周时测量UCD。对照组为常规筛查中染色体非整倍体低风险胎儿，出生后证实无染色体非整倍体。
21 -三体胎儿的UCD均值低于正常胎儿，但两者之间无显著差异（7.48±0.99 mm对7.66±0.91 mm；P = 0.41）。UCD均值在其他母体变量（如体重指数和产科病史）之间无显著差异。有剖宫产史的母亲的UCD均值显著低于无剖宫产史的母亲（7.21±0.97对7.71±0.97；P = 0.03）。
在妊娠17 - 19周时，21 -三体胎儿的UCD比正常胎儿细，但这种差异的重要性太小，无法用于筛查。
