Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, España.
Rev Esp Enferm Dig. 2020 Jan;112(1):53-58. doi: 10.17235/reed.2019.6655/2019.
Microscopic colitis is a common cause of chronic watery diarrhea with a great impact on patient quality of life. Microscopic colitis includes two histological subtypes: collagenous colitis and lymphocytic colitis. Due to the increasing incidence and awareness of this disease over the last decades, several international guidelines have been recently published. However, there is still significant heterogeneity in the management of these patients, and treatments without solid scientific evidence support are often used in clinical practice. This article reviews the therapeutic role of budesonide in microscopic colitis and summarizes the current evidence regarding other treatments available for this disease, especially for the management of refractory patients. Finally, an updated treatment algorithm is proposed.
显微镜结肠炎是一种常见的慢性水样腹泻病因，对患者的生活质量有重大影响。显微镜结肠炎包括两种组织学亚型：胶原性结肠炎和淋巴细胞性结肠炎。由于在过去几十年中这种疾病的发病率和认知度不断提高，最近已经发表了几项国际指南。然而，对于这些患者的管理仍然存在显著的异质性，并且在临床实践中经常使用没有坚实科学证据支持的治疗方法。本文综述了布地奈德在显微镜结肠炎中的治疗作用，并总结了目前关于这种疾病的其他治疗方法的证据，特别是针对难治性患者的管理。最后提出了一个更新的治疗方案。
