Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
DNA Cell Biol. 2020 Feb;39(2):197-209. doi: 10.1089/dna.2019.4745. Epub 2019 Dec 26.
Propofol is a widely used intravenous agent for the induction and maintenance of anesthesia. An increasing number of studies have shown that propofol modulates autophagy, which is an evolutionarily conserved catabolic process that maintains cellular homeostasis by degrading long-lived proteins and damaged cellular proteins or organelles. Extensive studies have been performed to better understand the regulation of autophagy by propofol, the majority of which have demonstrated that the effects of propofol on autophagy are beneficial to organs and tissues. In this review, we retrospectively analyzed studies to assess the effects of propofol on autophagy in different diseases and evaluated the underlying mechanisms.
丙泊酚是一种广泛应用于麻醉诱导和维持的静脉麻醉药物。越来越多的研究表明，丙泊酚能调节自噬，自噬是一种进化上保守的降解途径，通过降解长寿命蛋白和受损的细胞蛋白或细胞器来维持细胞内环境的稳定。为了更好地理解丙泊酚对自噬的调节作用，已经进行了广泛的研究，其中大多数研究表明丙泊酚对自噬的影响对器官和组织是有益的。在这篇综述中，我们回顾性分析了评估丙泊酚在不同疾病中对自噬影响的研究，并评估了潜在的机制。
