Echenique J E, Graham S D
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia.
Urology. 1988 Nov;32(5):397-400. doi: 10.1016/0090-4295(88)90408-6.
Numerous neoplasms, including colonic, lung, stomach, and prostate, have been found to have increased concentrations of lipid-associated sialic acid (LASA). CA 19-9 is a carbohydrate antigen found on the membrane surface of pancreatic, gastric, and colonic cancers. A prospective study involving 25 patients (15 males, 10 females) with renal cell carcinoma (RCC) was undertaken to examine the clinical value of these two markers. Patients' ages ranged from twenty-five to seventy-seven years (mean 56 years). The group consisted of 9 Stage I, 1 Stage II, 5 Stage III, and 10 Stage IV patients. Twenty three of the 25 had known disease present when tested. Eleven patients with no known tumor were used as an age-matched control group. Sixteen of the 23 patients with known disease (70%) had elevated LASA values. Nine of the 11 control patients (82%) had normal LASA values. Three of 7 patients with values obtained pre- and post-nephrectomy showed levels returned to normal after nephrectomy; 3 had persistent LASA elevation and were found to have either metastatic or recurrent disease, and 1 had a persistent elevation of his LASA value without known metastatic or recurrent disease. When the 23 patients with known disease were compared according to stage, 62 percent of Stages I and II, 80 percent of Stage III, and 70 percent of Stage IV had elevated LASA values. There was no statistically significant difference between LASA values and tumor stage. CA 19-9 values obtained in 15 of 25 patients with RCC were within normal range.
人们发现，包括结肠癌、肺癌、胃癌和前列腺癌在内的许多肿瘤中，脂质相关唾液酸（LASA）的浓度都有所增加。CA 19-9是一种在胰腺癌、胃癌和结肠癌膜表面发现的碳水化合物抗原。一项针对25例肾细胞癌（RCC）患者（15例男性，10例女性）的前瞻性研究，旨在检验这两种标志物的临床价值。患者年龄在25岁至77岁之间（平均56岁）。该组包括9例I期、1例II期、5例III期和10例IV期患者。25例患者中有23例在检测时已知患有疾病。11例无已知肿瘤的患者作为年龄匹配的对照组。23例已知疾病的患者中有16例（70%）LASA值升高。11例对照患者中有9例（82%）LASA值正常。7例肾切除术前和术后进行检测的患者中，3例术后LASA水平恢复正常；3例LASA持续升高，被发现有转移或复发性疾病，1例LASA值持续升高，但无已知转移或复发性疾病。根据分期对23例已知疾病的患者进行比较时，I期和II期患者中有62%、III期患者中有80%、IV期患者中有70%的LASA值升高。LASA值与肿瘤分期之间无统计学显著差异。25例RCC患者中有15例的CA 19-9值在正常范围内。
