Unit on Neuron-Glia Interactions in Retinal Disease, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Adv Exp Med Biol. 2019;1185:33-37. doi: 10.1007/978-3-030-27378-1_6.
The complement system, commonly associated with innate immune responses to invading pathogens, has been found in the CNS to exert a host of noncanonical functions influential during development and disease. In the retina, local complement expression and activation have been detected in response to injury, and polymorphisms in complement genes have also been linked to the genetic risk for retinal disease. While knowledge regarding the functions, effects, and mechanisms underlying complement in the retina is incomplete, complement expression and activation have been intriguingly linked to both increases and decreases in retinal degeneration in separate contexts and model systems. Here we review the evidence for the varying adaptive and maladaptive contributions of complement and comment on the implications for therapeutic strategies at complement modulation in retinal pathologies.
补体系统通常与先天免疫反应入侵病原体有关，现已在中枢神经系统中发现其具有一系列非典型功能，在发育和疾病过程中发挥重要作用。在视网膜中，局部补体表达和激活已被检测到对损伤的反应，并且补体基因的多态性也与视网膜疾病的遗传风险相关。尽管关于补体在视网膜中的功能、作用和机制的知识尚不完整，但补体的表达和激活已在不同的背景和模型系统中与视网膜变性的增加和减少都有关联。在这里，我们综述了补体的这些不同的适应性和失调性作用的证据，并就补体调节在视网膜病变中的治疗策略的意义进行了评论。
