组蛋白去乙酰化酶抑制剂诱导自噬可能不是 P23H 视紫红质引起的视网膜变性预防作用的机制。
Autophagy Induction by HDAC Inhibitors Is Unlikely to be the Mechanism of Efficacy in Prevention of Retinal Degeneration Caused by P23H Rhodopsin.
机构信息
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
出版信息
Adv Exp Med Biol. 2019;1185:401-405. doi: 10.1007/978-3-030-27378-1_66.
We previously found that valproic acid (VPA) and other histone deacetylase inhibitors (HDACis) ameliorate retinal degeneration (RD) caused by P23H rhodopsin in Xenopus laevis larvae and hypothesized that this may be due to enhancement of autophagy. Here we use X. laevis expressing an autophagy marker to assess effects of HDACis on autophagy. We also assess the effects of non-HDACi activators and inducers of autophagy on RD caused by P23H rhodopsin.
我们之前发现丙戊酸（VPA）和其他组蛋白去乙酰化酶抑制剂（HDACi）可以改善非洲爪蟾幼虫 P23H 视紫红质引起的视网膜变性（RD），并假设这可能是由于自噬增强所致。在这里，我们使用表达自噬标志物的非洲爪蟾来评估 HDACi 对自噬的影响。我们还评估了非 HDACi 自噬激活剂和诱导剂对 P23H 视紫红质引起的 RD 的影响。
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