Baud D, Ammerdorffer A, Buffe Y, Vouga M, Greub G, Stojanov M
Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, Switzerland.
Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics, Vrije Universiteit Amsterdam, the Netherlands.
New Microbes New Infect. 2019 Nov 23;33:100619. doi: 10.1016/j.nmni.2019.100619. eCollection 2020 Jan.
The intracellular bacterium , which belongs to the order, was found to be associated with miscarriage in humans. There is little to no knowledge regarding the mode of infection, impact on the neonate and pathophysiology of this emerging bacterium. We have previously shown that induces a systemic infection, organ pathology and elicits T helper type 1-associated humoral immunity in a murine model of genital infection. In the present study, we took advantage of this model of infection to evaluate the impact of this bacterium on the mouse pregnancy. We used two routes of inoculation, vaginal and intrauterine, to introduce infection before and after mating. Our results show that genital infection by did not have any significant impact on gestation length and maternal weight gain, nor on the number of offspring and their weight. This observation indicates that the mouse model of infection is not suitable to study the effect of on pregnancy and alternative models of infection, including ones, should be used. Moreover, an indirect immunopathological mechanism activated by this bacterium should be further explored.
这种属于该菌目的细胞内细菌被发现与人类流产有关。关于这种新出现细菌的感染方式、对新生儿的影响以及病理生理学，人们知之甚少。我们之前已经表明，在生殖器感染的小鼠模型中，该细菌会引发全身感染、器官病变并引发1型辅助性T细胞相关的体液免疫。在本研究中，我们利用这种感染模型来评估该细菌对小鼠妊娠的影响。我们采用阴道和子宫内两种接种途径，在交配前后引入感染。我们的结果表明，该细菌引起的生殖器感染对妊娠期长度、母体体重增加、后代数量及其体重均无显著影响。这一观察结果表明，该感染小鼠模型不适用于研究该细菌对妊娠的影响，应该使用包括其他模型在内的替代感染模型。此外，应由该细菌激活的间接免疫病理机制应进一步探索。
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