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Synthesis of guanosine 5'-diphosphate, 3'-diphosphate in spot mutants of Escherichia coli.

作者信息

de Boer H A, Weyer W J, de Boer J G, van der Heide S, Gruber M

出版信息

Biochim Biophys Acta. 1977 Jan 20;474(2):165-72. doi: 10.1016/0005-2787(77)90190-3.

DOI:10.1016/0005-2787(77)90190-3
PMID:318860
Abstract

The synthesis of ppGpp in spoT- mutants of Escherichia coli has been invesitgated. In these mutants the first-order rate constant for ppGpp breakdown is low, and pppGpp is barely detectable. It is shown that the rate of pppGpp, and hence ppGpp, synthesis is strongly reduced compared with that observed in spot+ strains. The low rate of magic spot synthesis satisfactorily explains the low levels of pppGpp in spoT- mutants. The pentaphosphate very probably is the precursor of ppGpp as it is in wild-type, i.e. spoT+, strains.

摘要

相似文献

1
Synthesis of guanosine 5'-diphosphate, 3'-diphosphate in spot mutants of Escherichia coli.
Biochim Biophys Acta. 1977 Jan 20;474(2):165-72. doi: 10.1016/0005-2787(77)90190-3.
2
Synthesis of pppGpp by ribosomes from an Escherichia coli spoT mutant and the metabolic relationship between pppGpp and ppGpp.来自大肠杆菌spoT突变体的核糖体对pppGpp的合成以及pppGpp与ppGpp之间的代谢关系。
Can J Biochem. 1977 Dec;55(12):1207-12. doi: 10.1139/o77-180.
3
The sequence of ppGpp and pppGpp in the reaction scheme for magic spot synthesis.魔斑合成反应体系中ppGpp和pppGpp的序列。
Biochim Biophys Acta. 1976 Aug 2;442(1):123-7. doi: 10.1016/0005-2787(76)90183-0.
4
Synthesis of guanosine 5'-triphosphate,3'-diphosphate in a spo T strain of Escherichia coli.
Can J Biochem. 1976 Nov;54(11):935-40. doi: 10.1139/o76-135.
5
Interaction of alleles of the relA, relC and spoT genes in Escherichia coli: analysis of the interconversion of GTP, ppGpp and pppGpp.大肠杆菌中relA、relC和spoT基因等位基因的相互作用：GTP、ppGpp和pppGpp相互转化的分析
Mol Gen Genet. 1977 Jan 7;150(1):87-101. doi: 10.1007/BF02425329.
6
Mutants of Escherichia coli defective in the degradation of guanosine 5'-triphosphate, 3'-diphosphate (pppGpp).在鸟苷5'-三磷酸3'-二磷酸（pppGpp）降解方面存在缺陷的大肠杆菌突变体。
Mol Gen Genet. 1979 Feb 1;169(3):315-23. doi: 10.1007/BF00382277.
7
[Role of spot gene product in the degradation of pppGpp in bacteria].[斑点基因产物在细菌中pppGpp降解中的作用]
Mol Biol (Mosk). 1982 Jul-Aug;16(4):857-64.
8
ppGpp cycle in Escherichia coli.大肠杆菌中的ppGpp循环。
Mol Gen Genet. 1977 Feb 15;150(3):249-55. doi: 10.1007/BF00268123.
9
Characterization of the guanosine 5'-triphosphate 3'-diphosphate and guanosine 5'-diphosphate 3'-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli.大肠杆菌中一种特定焦磷酸化酶催化的鸟苷 5'-三磷酸 3'-二磷酸和鸟苷 5'-二磷酸 3'-二磷酸降解反应的特性研究
Biochemistry. 1978 Dec 12;17(25):5368-72. doi: 10.1021/bi00618a007.
10
Degradation of guanosine 3'-diphosphate 5'-diphosphate in vitro by the spoT gene product of Escherichia coli.大肠杆菌spoT基因产物在体外对鸟苷3'-二磷酸5'-二磷酸的降解作用。
Eur J Biochem. 1978 Aug 15;89(1):125-31. doi: 10.1111/j.1432-1033.1978.tb20904.x.

引用本文的文献

1
Influence of amino acid starvation on guanosine 5'-diphosphate 3'-diphosphate basal-level synthesis in Escherichia coli.氨基酸饥饿对大肠杆菌中鸟苷5'-二磷酸3'-二磷酸基础水平合成的影响。
J Bacteriol. 1980 Nov;144(2):499-508. doi: 10.1128/jb.144.2.499-508.1980.
2
Mutants of Escherichia coli defective in the degradation of guanosine 5'-triphosphate, 3'-diphosphate (pppGpp).在鸟苷5'-三磷酸3'-二磷酸（pppGpp）降解方面存在缺陷的大肠杆菌突变体。
Mol Gen Genet. 1979 Feb 1;169(3):315-23. doi: 10.1007/BF00382277.