Memon Anza B, Madani Sarah, Ahmad Bashiruddin K, Grover Kavita, Arcila-Londono Ximena, Schultz Lonni, Sripathi Naganand
Department of Neurology, Henry Ford Health System, Detroit, MI, USA.
Wayne State University, School of Medicine, Detroit, MI, USA.
Clin Neurophysiol Pract. 2019 Sep 9;4:190-193. doi: 10.1016/j.cnp.2019.08.002. eCollection 2019.
To evaluate sensory electrophysiology, terminal latency index (TLI), and treatment response in idiopathic and diabetic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
We performed a retrospective review of 147 patients with CIDP who underwent electrodiagnostic evaluation (January 2000-December 2015). Eighty-nine patients fulfilled electrophysiological criteria described by the Ad hoc Subcommittee of the American Academy of Neurology and Albers et al. Fifty-eight patients were divided into idiopathic (N = 40) and diabetic (N = 18) groups. These groups were compared for age, sex, cerebrospinal fluid protein, response to treatment, sensory response abnormalities, and TLI measurements using chi-square tests for binary and categorical variables and using t-tests and mixed-effects models for continuous variables.
The difference in abnormal rates of sensory responses was significant for the sural nerve, with the idiopathic group having a lower rate than the diabetic group (80% vs. 100%, p < 0.001). No group differences in the TLI measurements were significant.
Sural sensory responses may have some value in differentiating idiopathic CIDP from diabetic CIDP. Larger prospective studies are needed to confirm our findings.
Our study suggests that abnormal sural sensory potentials may have some significance in differentiating idiopathic CIDP from diabetic CIDP.
评估特发性和糖尿病性慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）的感觉电生理、终末潜伏期指数（TLI）及治疗反应。
我们对147例接受电诊断评估的CIDP患者进行了回顾性研究（2000年1月至2015年12月）。89例患者符合美国神经病学学会特设小组委员会及阿尔伯斯等人描述的电生理标准。58例患者分为特发性组（N = 40）和糖尿病组（N = 18）。使用卡方检验分析二元和分类变量，使用t检验和混合效应模型分析连续变量，比较两组患者的年龄、性别、脑脊液蛋白、治疗反应、感觉反应异常及TLI测量值。
腓肠神经感觉反应异常率差异有统计学意义，特发性组低于糖尿病组（80%对100%，p < 0.001）。两组TLI测量值差异无统计学意义。
腓肠神经感觉反应在鉴别特发性CIDP和糖尿病性CIDP方面可能有一定价值。需要更大规模的前瞻性研究来证实我们的发现。
我们的研究表明，异常的腓肠神经感觉电位在鉴别特发性CIDP和糖尿病性CIDP方面可能有一定意义。
