Lee Ji Yoon, Hong Seok-Ho
CHA Advanced Research Institute, CHA University, Seongnam, Korea.
Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.
Int J Stem Cells. 2020 Mar 30;13(1):1-12. doi: 10.15283/ijsc19127.
Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is unarguably regarded as an important cell source in stem cell biology. So far, many investigators are exploring HSCs and modified HSCs for use in clinical and basic science. In the present review, we briefly summarized HSCs and their application in pathophysiologic conditions, including non-hematopoietic tissue regeneration as well as blood disorders. HSCs and HSCs-derived progenitors are promising cell sources in regenerative medicine and their contributions can be properly applied to treat pathophysiologic conditions. Among many adult stem cells, HSCs are a powerful tool to treat patients with diseases such as hematologic malignancies and liver disease. Since HSCs can be differentiated into diverse progenitors including endothelial progenitors, they may be useful for constructing strategies for effective therapy.
造血干细胞（HSCs）被视为治疗再生性疾病的重要细胞来源之一。在众多干细胞中，使用成体来源的造血干细胞进行治疗的可行性多种多样，并且无疑被视为干细胞生物学中的重要细胞来源。到目前为止，许多研究人员正在探索造血干细胞和经过修饰的造血干细胞在临床和基础科学中的应用。在本综述中，我们简要总结了造血干细胞及其在病理生理状况中的应用，包括非造血组织再生以及血液疾病。造血干细胞及其衍生的祖细胞是再生医学中很有前景的细胞来源，它们的作用可以恰当地应用于治疗病理生理状况。在众多成体干细胞中，造血干细胞是治疗血液系统恶性肿瘤和肝脏疾病等患者的有力工具。由于造血干细胞可以分化为包括内皮祖细胞在内的多种祖细胞，它们可能有助于构建有效的治疗策略。
