25-羟维生素 D 水平与血液透析慢性肾脏病患者睡眠障碍相关：一项横断面研究。
25-Hydroxy vitamin D level is associated with sleep disturbances in patients with chronic kidney disease on hemodialysis: a cross-sectional study.
机构信息
Clinic of Internal Medicine, Samsun Education and Training Center, University of Health Sciences, Samsun, Turkey
Department of Family Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey
出版信息
Turk J Med Sci. 2020 Apr 9;50(2):298-303. doi: 10.3906/sag-1908-87.
BACKGROUND/AIM: Deficient levels of vitamin D are an important factor in the pathogenesis of some neurodegenerative diseases. The aim of this study is to determine the relationship between vitamin D deficiency and depression status and sleep disorders of patients on dialysis.
MATERIALS AND METHODS
In this cross-sectional study, 121 hemodialysis patients were enrolled. All patients had been on hemodialysis for at least six months at the time of the study. Sleep quality and depression status were measured by using specific inventories. All the patients filled out Pittsburg Sleep Quality Index (PSQI) and Beck Depression Inventory (BDI), and gave blood samples. Vitamin D levels were measured for 121 patients, and statistical analysis was done by using SPSS.
RESULTS
Regression analyses demonstrated that low levels of 25(OH)D and high BDI score were independent risk factors for poor sleep quality [ORs were 0.668 (0.566–0.789), 1.080 (1.001–1.164), and 1.080 (1.001–1.164), respectively].
CONCLUSION
Our results suggest that deficiency of 25(OH)D is an important independent risk factor for poor sleep quality in hemodialysis patients.
背景/目的：维生素 D 水平不足是一些神经退行性疾病发病机制中的一个重要因素。本研究旨在确定维生素 D 缺乏与透析患者的抑郁状态和睡眠障碍之间的关系。
材料与方法
在这项横断面研究中，纳入了 121 名血液透析患者。所有患者在研究时均已接受血液透析至少六个月。使用特定的量表来评估睡眠质量和抑郁状态。所有患者均填写匹兹堡睡眠质量指数（PSQI）和贝克抑郁量表（BDI），并采集血样。对 121 名患者进行维生素 D 水平检测，采用 SPSS 进行统计分析。
结果
回归分析表明，25（OH）D 水平低和 BDI 评分高是睡眠质量差的独立危险因素[比值比（ORs）分别为 0.668（0.566–0.789）、1.080（1.001–1.164）和 1.080（1.001–1.164）]。
结论
我们的研究结果表明，25（OH）D 缺乏是血液透析患者睡眠质量差的一个重要独立危险因素。
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