Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA.
Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA.
BMC Med Imaging. 2019 Dec 30;19(1):101. doi: 10.1186/s12880-019-0404-7.
Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI.
4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66 ± 12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40 ± 16yo; retrospective from 2010 to 2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates.
Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P = 0.01) and apex (fitted reduction = 1.4 L/min; P = 0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P = 0.01).
A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.
急性心肌梗死（AMI）改变左心室（LV）血流动力学，导致整体 LV 射血分数和整体 LV 动能降低。我们假设前壁 AMI 会影响 LV 局部血流，并采用 4D 流 MRI 分析这些局部变化的区域方法。
比较 12 例前壁 AMI 患者（11 名男性；66±12 岁；前瞻性采集于 2016-2017 年）和 19 名健康志愿者（10 名男性；40±16 岁；回顾性采集于 2010-2011 年研究）的 4D 流心脏磁共振（CMR）数据。在短轴电影稳态自由进动 CMR 上对 LV 腔进行轮廓描绘，并将其分为三个区域：基底、中间心室和心尖。将 4D 流数据注册到短轴分段。使用年龄、性别和心率作为协变量的流量线性模型，对组间各区域的收缩期和舒张期峰值血流进行比较。
与对照组相比，前壁 AMI 患者的 LV 中部（拟合减少量=3.9 L/min；P=0.01）和心尖（拟合减少量=1.4 L/min；P=0.02）的收缩期峰值血流减少。与对照组相比，前壁 AMI 患者的舒张期峰值血流也在心尖处较低（拟合减少量=2.4 L/min；P=0.01）。
应用 4D LV 流数据分析的区域方法在前壁 AMI 患者和对照组中进行。与对照组相比，前壁 AMI 患者的局部血流减少。
Zotero 插件
