Thalambedu Nishanth, Khan Yasir, Zhang Qian, Khanal Shristi, Ashfaq Ammar
Internal Medicine, Abington Hospital - Jefferson Health, Abington, USA.
Internal Medicine, Abington Hospital, Jefferson Health, Abington, USA.
Cureus. 2019 Nov 26;11(11):e6233. doi: 10.7759/cureus.6233.
Melanoma is a deadly disease with immunotherapy treatment options that emerged in the last few years and have changed the disease outcome. However, it is associated with immune-related toxic effects despite improving survival. We present the case of a 53-year-old woman who had two weeks of diarrhea after she was treated with dual immunotherapy agents for her advanced melanoma. The final workup revealed pancolitis, possibly due to immunotherapy adverse effects. Initial conservative treatment, unfortunately, did not lead to a clinical improvement until a steroid was introduced. We are reporting this case to alert our fellow physicians about the immune-mediated toxicities of the relatively new checkpoint inhibitors.
黑色素瘤是一种致命疾病，免疫疗法是近年来出现的治疗选择，改变了该病的预后。然而，尽管提高了生存率，但它与免疫相关的毒性作用有关。我们报告了一名53岁女性的病例，她在接受晚期黑色素瘤双重免疫治疗药物治疗后出现了两周的腹泻。最终检查显示为全结肠炎，可能是免疫治疗的不良反应所致。不幸的是，最初的保守治疗直到使用类固醇才导致临床改善。我们报告这个病例是为了提醒我们的同行注意相对较新的检查点抑制剂的免疫介导毒性。
