Ilgisonis Ekaterina, Kiseleva Olga, Kuznetsova Ksenia
Institute of Biomedical Chemistry, 10/8 Pogodinskaya, Moscow, Russia.
EuPA Open Proteom. 2019 Aug 17;22-23:25-27. doi: 10.1016/j.euprot.2019.07.011. eCollection 2019 Mar.
This work on solving the mystery of words encoded by amino acids in peptides was derived by the YPIC-EuPA Challenge. We received a dry synthetic peptide sample and performed a mass spectrometric analysis followed by peptide sequencing. As a result, a part of "Rays of positive electricity and their application to chemical analyses" by J.J.Tomson was found to be encoded in the peptides of the sample. The words were first revealed from the peptides, that matched by Google search to find the answer. After that, the answer was validated using a standard proteomic search against a database constructed from the quotation found.
这项关于解开肽中氨基酸编码单词之谜的工作源自YPIC-EuPA挑战赛。我们收到了一个干燥的合成肽样本，进行了质谱分析，随后进行了肽测序。结果发现，样本肽中编码了J.J.汤姆森的《正电射线及其在化学分析中的应用》的一部分内容。这些单词首先从肽中被揭示出来，通过谷歌搜索进行匹配以找到答案。之后，使用标准蛋白质组学搜索对根据找到的引文构建的数据库进行验证，从而验证了答案。
