College of Sport Science, Sungkyunkwan University, Suwon, Republic of Korea.
Diabetes Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, NY, USA; Department of Food and Nutrition, Hannam University, Daejeon, 306-791, Republic of Korea.
J Steroid Biochem Mol Biol. 2020 Apr;198:105569. doi: 10.1016/j.jsbmb.2019.105569. Epub 2019 Dec 28.
The prevalence of non-alcoholic fatty liver disease (NAFLD) tends to increase with age, but little is known regarding relations between the risk of NAFLD in older adults and serum vitamin D (25-hydroxyvitamin D) and physical fitness levels. The aim of this study was to investigate the relationship between NAFLD risk and serum vitamin D levels combined with physical fitness in elderly adults using a non-invasive diagnostic approach. We enrolled 533 Korean older adults (80.8 % women), aged 65 years or older in this cross-sectional study. NAFLD in absence of another cause of liver disease was defined according to the ZJU and NAFLD liver fat (LFS) score. Physical fitness was assessed using a senior fitness test protocol. Logistic regression analysis was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) of NAFLD for different combinations of serum vitamin D and physical fitness levels. According to the ZJU (OR: 3.073, CI: 1.285-7.350, p = 0.012) and LFS (OR = 2.443, CI = 1.071-5.572, p = 0.034), individuals with serum vitamin D < 30 ng/ml and poor physical fitness had a significantly higher risk of NAFLD than individuals with serum vitamin D ≥ 30 ng/ml and high fitness (reference, OR = 1), even after adjustments for age, sex, smoking, alcohol consumption and physical inactivity. However, there was no significant association after adjustment for additional metabolic diseases. Our findings suggest that the maintenance of appropriate levels of serum vitamin D and/or high physical fitness and the monitoring metabolic diseases can help reduce the risk of NAFLD in older adults.
非酒精性脂肪性肝病 (NAFLD) 的患病率往往随着年龄的增长而增加，但对于老年人 NAFLD 风险与血清维生素 D（25-羟维生素 D）和身体适应水平之间的关系知之甚少。本研究旨在使用非侵入性诊断方法探讨老年人群中 NAFLD 风险与血清维生素 D 水平和身体适应水平之间的关系。我们纳入了这项横断面研究中的 533 名韩国老年人（80.8%为女性），年龄在 65 岁及以上。根据 ZJU 和 NAFLD 肝脂肪 (LFS) 评分标准，无其他肝脏疾病原因的 NAFLD 定义为 NAFLD。身体适应水平通过老年人体适能测试方案进行评估。使用逻辑回归分析估计不同血清维生素 D 和身体适应水平组合下 NAFLD 的比值比 (OR) 和 95%置信区间 (CI)。根据 ZJU（OR：3.073，CI：1.285-7.350，p=0.012）和 LFS（OR=2.443，CI：1.071-5.572，p=0.034），血清维生素 D<30ng/ml 且身体适应水平较差的个体患 NAFLD 的风险明显高于血清维生素 D≥30ng/ml 且身体适应水平较高的个体（参考，OR=1），即使在调整年龄、性别、吸烟、饮酒和身体不活动后也是如此。然而，在调整了其他代谢性疾病后，这种关联并不显著。我们的研究结果表明，维持适当的血清维生素 D 水平和/或较高的身体适应水平以及监测代谢性疾病可以帮助降低老年人患 NAFLD 的风险。
