Department of Ultrasonography, The People 's Hospital of Han chuan, Hubei, China.
Department of Respiratory, The People 's Hospital of Han chuan, Hubei, China.
Am J Emerg Med. 2020 Mar;38(3):589-593. doi: 10.1016/j.ajem.2019.11.036. Epub 2019 Nov 29.
The efficacy of Nigella sativa supplementation for asthma control remains controversial. We conduct a systematic review and meta-analysis to explore the influence of Nigella sativa supplementation on asthma control.
We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through June 2019 for randomized controlled trials (RCTs) assessing the efficacy of Nigella sativa supplementation for asthma control. This meta-analysis is performed using the random-effect model.
Four RCTs are included in the meta-analysis. Overall, compared with control group for asthma, Nigella sativa supplementation is associated with increased ACT scores (Std. MD = 0.50; 95% CI = 0.11 to 0.88; P = 0.01), FEV1 (Std. MD = 1.84; 95% CI = 0.07 to 3.60; P = 0.04), but demonstrates no obvious impact on PEF (Std. MD = 3.11; 95% CI = -1.30 to 7.52; P = 0.17), IL-4 (Std. MD = -0.31; 95% CI = -1.21 to 0.59; P = 0.50), or IFN-γ (Std. MD = 1.11; 95% CI = -0.44 to 2.67; P = 0.16).
Nigella sativa supplementation may provide additional benefits for the treatment of asthma.
黑种草籽（Nigella sativa）补充剂对哮喘控制的疗效仍存在争议。我们进行了一项系统评价和荟萃分析，以探讨黑种草籽补充剂对哮喘控制的影响。
我们通过检索 PubMed、EMbase、Web of Science、EBSCO 和 Cochrane 图书馆数据库，截至 2019 年 6 月，查找评估黑种草籽补充剂对哮喘控制疗效的随机对照试验（RCT）。本荟萃分析采用随机效应模型进行。
共有 4 项 RCT 纳入荟萃分析。总体而言，与对照组相比，黑种草籽补充剂与 ACT 评分的增加相关（标准均数差 [Std. MD] = 0.50；95%置信区间 [CI] = 0.11 至 0.88；P = 0.01），FEV1（Std. MD = 1.84；95% CI = 0.07 至 3.60；P = 0.04），但对 PEF（Std. MD = 3.11；95% CI = -1.30 至 7.52；P = 0.17）、IL-4（Std. MD = -0.31；95% CI = -1.21 至 0.59；P = 0.50）或 IFN-γ（Std. MD = 1.11；95% CI = -0.44 至 2.67；P = 0.16）没有明显影响。
黑种草籽补充剂可能为哮喘治疗提供额外益处。
