黑种草子对血糖控制、血脂谱以及炎症和氧化应激生物标志物的影响：一项随机对照临床试验的系统评价和荟萃分析。
Effects of Nigella sativa on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials.
机构信息
Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran.
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Phytother Res. 2020 Oct;34(10):2586-2608. doi: 10.1002/ptr.6708. Epub 2020 May 11.
The aim of this systematic review and meta-analysis was to evaluate the effects of Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until October 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of the studied trials. The heterogeneity among the included studies were assessed using the Cochrane's Q test and I-square (I ) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. A total of 50 trials were included in this meta-analysis. We found a significant reduction in total cholesterol (WMD: -16.80; 95% CI: -21.04, -12.55), triglycerides (WMD: -15.73; 95% CI: -20.77, -10.69), LDL-cholesterol (WMD: -18.45; 95% CI: -22.44, -14.94) and VLDL-cholesterol (WMD: -3.72; 95% CI: -7.27, -0.18) following supplementation with N. sativa. In addition, there was significant reductive effect observed with N. sativa on fasting glucose (WMD: -15.18; 95% CI: -19.82, -10.55) and HbA1C levels (WMD: -0.45; 95% CI: -0.66, -0.23). Effects of N. sativa on CRP (WMD: -3.61; 95% CI: -9.23, 2.01), TNF-α (WMD: -1.18; 95% CI: -3.23, 0.86), TAC (WMD: 0.31; 95% CI: 0.00, 0.63), and MDA levels (WMD: -0.95; 95% CI: -2.18, 0.27) were insignificant. This meta-analysis demonstrated the beneficial effects of N. sativa on fasting glucose, HbA1c, triglycerides, total-, VLDL-, LDL-cholesterol levels.
本系统评价和荟萃分析的目的是评估黑种草（N. sativa）对血糖控制、血脂谱以及炎症和氧化应激生物标志物的影响。两位独立作者系统地查阅了在线数据库，包括 EMBASE、Scopus、PubMed、Cochrane 图书馆和 Web of Science，从成立到 2019 年 10 月 30 日。应用 Cochrane 协作风险偏倚工具评估研究试验的方法学质量。使用 Cochrane 的 Q 检验和 I 平方（I ）统计量评估纳入研究的异质性。使用随机效应模型汇总数据，并考虑加权均数差（WMD）作为总体效应大小。这项荟萃分析共纳入 50 项试验。我们发现，总胆固醇（WMD：-16.80；95%CI：-21.04，-12.55）、甘油三酯（WMD：-15.73；95%CI：-20.77，-10.69）、LDL-胆固醇（WMD：-18.45；95%CI：-22.44，-14.94）和 VLDL-胆固醇（WMD：-3.72；95%CI：-7.27，-0.18）均有显著降低。此外，黑种草补充剂还显著降低了空腹血糖（WMD：-15.18；95%CI：-19.82，-10.55）和 HbA1c 水平（WMD：-0.45；95%CI：-0.66，-0.23）。黑种草对 CRP（WMD：-3.61；95%CI：-9.23，2.01）、TNF-α（WMD：-1.18；95%CI：-3.23，0.86）、TAC（WMD：0.31；95%CI：0.00，0.63）和 MDA 水平（WMD：-0.95；95%CI：-2.18，0.27）的影响不显著。这项荟萃分析表明，黑种草对空腹血糖、HbA1c、甘油三酯、总胆固醇、VLDL-胆固醇、LDL-胆固醇水平有有益作用。
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