长非编码 RNA 功能超越序列：JpX 模型：对 Karner 等人（2019 年）发表的“尽管 lncRNA JPX 的序列和结构存在差异，但功能仍保守”一文的评论。

Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on "Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence" by Karner et al. (2019).

机构信息

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Genetics, Harvard Medical School, Boston, MA, USA.

出版信息

J Mol Biol. 2020 Jan 17;432(2):301-304. doi: 10.1016/j.jmb.2019.11.011. Epub 2019 Nov 30.

DOI:10.1016/j.jmb.2019.11.011

PMID:31892474

Abstract

The mouse lncRNA Jpx has been shown as an essential regulator in X-chromosome inactivation (XCI). Jpx RNA activates Xist expression through its trans-acting ability to evict CTCF from Xist promoter. Karner et al. (2019) reveals the intriguing finding that human JPX and mouse Jpx are functionally conserved although they have low similarity in the primary sequence and the secondary structure. This study provides an excellent model for studying lncRNA's evolution and epigenetic function.

摘要

小鼠 lncRNA Jpx 已被证明是 X 染色体失活（XCI）的重要调节因子。Jpx RNA 通过其反式作用能力从 Xist 启动子中驱逐 CTCF，从而激活 Xist 的表达。Karner 等人（2019 年）揭示了一个有趣的发现，即尽管人类 JPX 和小鼠 Jpx 在一级序列和二级结构上相似度较低，但它们在功能上是保守的。这项研究为研究 lncRNA 的进化和表观遗传功能提供了一个极好的模型。