Ochiai Sho, Sugawara Hiroko, Kajio Yusuke, Tanaka Hibiki, Ishikawa Tomohisa, Fukuhara Ryuji, Jono Tadashi, Hashimoto Mamoru
1Department of Neuropsychiatry, Kumamoto University Hospital, Kumamoto, Japan.
Yatsushiro Hospital, Yatsushiro, Japan.
Ann Gen Psychiatry. 2019 Dec 30;18:29. doi: 10.1186/s12991-019-0253-3. eCollection 2019.
Dementia with Lewy bodies (DLB) is characterized by fluctuating cognitive impairments, recurrent visual hallucinations, the motor symptoms of parkinsonism and REM sleep behavior disorder. Various neuropsychiatric symptoms including hallucination and delusions occur frequently; however, delusional parasitosis is rare in DLB. Here, we report a case of DLB patient with delusional parasitosis.
The patient was an 89-year-old woman. At the age of 88, she began to complain her oral cenesthopathy, and developed cognitive decline, delusional parasitosis and parkinsonism. As a result of examination, she was diagnosed as DLB and treated with combination of donepezil 5 mg/day and aripiprazole 1.5 mg/day, and her complaint was disappeared.
Further studies are needed to investigate the association between delusional parasitosis and underlying pathophysiology of DLB, and the utility of antipsychotics for delusional parasitosis in DLB has to be examined through more cases.
路易体痴呆（DLB）的特征为认知障碍波动、反复出现视幻觉、帕金森氏症的运动症状以及快速眼动睡眠行为障碍。包括幻觉和妄想在内的各种神经精神症状经常出现；然而，妄想性寄生虫病在DLB中较为罕见。在此，我们报告一例患有妄想性寄生虫病的DLB患者。
该患者为一名89岁女性。88岁时，她开始抱怨口腔内有异样感觉，并出现认知衰退、妄想性寄生虫病和帕金森氏症。经检查，她被诊断为DLB，并接受了每天5毫克多奈哌齐和1.5毫克阿立哌唑的联合治疗，其症状消失。
需要进一步研究来调查妄想性寄生虫病与DLB潜在病理生理学之间的关联，并且必须通过更多病例来检验抗精神病药物对DLB中妄想性寄生虫病的效用。
