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沙利度胺治疗血管发育异常相关的复发性胃肠道出血:低剂量是一种安全可行的选择吗?

Thalidomide for the treatment of angiodysplasia-related recurrent gastrointestinal hemorrhage: Is low dose a safe and viable option?

作者信息

Patel Harish, Mehershahi Shehriyar, Shaikh Danial Haris, Makker Jasbir, Nayudu Sureshkumar, Remy Prospere, Chilimuri Sridhar

机构信息

Division of Gastroenterology BronxCare Hospital Center a Clinical Affiliate of Mt Sinai Health Systems and Academic affiliate of Icahn School of Medicine Bronx New York.

Department of Medicine BronxCare Hospital Center a Clinical Affiliate of Mt Sinai Health Systems and Academic affiliate of Icahn School of Medicine Bronx New York.

出版信息

Clin Case Rep. 2019 Oct 23;7(12):2363-2367. doi: 10.1002/ccr3.2501. eCollection 2019 Dec.

Abstract

Thalidomide is often used for the management of refractory gastrointestinal angiodysplasia (GIAD). The tolerance, toxic profile, and compliance of thalidomide are dose-dependent. The low-dose thalidomide (50 mg) is safe and a viable option for bleeding related to GIAD.

摘要

沙利度胺常用于难治性胃肠道血管发育异常(GIAD)的治疗。沙利度胺的耐受性、毒性特征和依从性呈剂量依赖性。低剂量沙利度胺(50毫克)安全,是治疗与GIAD相关出血的可行选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/9deb38735b76/CCR3-7-2363-g001.jpg

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