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沙利度胺治疗血管发育异常相关的复发性胃肠道出血：低剂量是一种安全可行的选择吗？

Thalidomide for the treatment of angiodysplasia-related recurrent gastrointestinal hemorrhage: Is low dose a safe and viable option?

作者信息

Patel Harish, Mehershahi Shehriyar, Shaikh Danial Haris, Makker Jasbir, Nayudu Sureshkumar, Remy Prospere, Chilimuri Sridhar

机构信息

Division of Gastroenterology BronxCare Hospital Center a Clinical Affiliate of Mt Sinai Health Systems and Academic affiliate of Icahn School of Medicine Bronx New York.

Department of Medicine BronxCare Hospital Center a Clinical Affiliate of Mt Sinai Health Systems and Academic affiliate of Icahn School of Medicine Bronx New York.

出版信息

Clin Case Rep. 2019 Oct 23;7(12):2363-2367. doi: 10.1002/ccr3.2501. eCollection 2019 Dec.

DOI:10.1002/ccr3.2501
PMID:31893059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6935600/
Abstract

Thalidomide is often used for the management of refractory gastrointestinal angiodysplasia (GIAD). The tolerance, toxic profile, and compliance of thalidomide are dose-dependent. The low-dose thalidomide (50 mg) is safe and a viable option for bleeding related to GIAD.

摘要

沙利度胺常用于难治性胃肠道血管发育异常（GIAD）的治疗。沙利度胺的耐受性、毒性特征和依从性呈剂量依赖性。低剂量沙利度胺（50毫克）安全，是治疗与GIAD相关出血的可行选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/12c7910a721b/CCR3-7-2363-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/9deb38735b76/CCR3-7-2363-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/3a6512c11a2e/CCR3-7-2363-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/b742d1e032da/CCR3-7-2363-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/12c7910a721b/CCR3-7-2363-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/9deb38735b76/CCR3-7-2363-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/3a6512c11a2e/CCR3-7-2363-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/b742d1e032da/CCR3-7-2363-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd28/6935600/12c7910a721b/CCR3-7-2363-g004.jpg

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本文引用的文献

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Successful Treatment of Recurrent Gastrointestinal Bleeding Due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide: Two Birds with One Stone.沙利度胺成功治疗小肠血管发育异常和多发性骨髓瘤所致复发性胃肠道出血：一石二鸟。
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Hereditary hemorrhagic telangiectasia: diagnosis and management from the hematologist's perspective.
遗传性出血性毛细血管扩张症：从血液学家的角度诊断和管理。
Haematologica. 2018 Sep;103(9):1433-1443. doi: 10.3324/haematol.2018.193003. Epub 2018 May 24.
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Pharmacological treatment of gastrointestinal bleeding due to angiodysplasias: A position paper of the Italian Society of Gastroenterology (SIGE).意大利胃肠病学会（SIGE）关于血管发育不良引起的胃肠道出血的药物治疗：立场文件。
Dig Liver Dis. 2018 Jun;50(6):542-548. doi: 10.1016/j.dld.2018.02.004. Epub 2018 Feb 15.
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Frontline Gastroenterol. 2018 Apr;9(2):98-104. doi: 10.1136/flgastro-2017-100870. Epub 2017 Nov 2.
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