Xu Nan, Xu Jie, Li Han, Qian Lijuan, Qiao Lixing
Department of Pediatrics, Wuxi Branch of Zhongda Hospital, South-east University, Wuxi, China.
Department of Pediatrics, Zhongda Hospital of Southeast University, Nanjing, China.
Pak J Pharm Sci. 2019 Sep;32(5(Special)):2385-2390.
The main aim of this study was to investigate the effects of human gamma globulin (HGG) on inflammation targets in children. A total of 80 children were randomly divided into observation and control group with 40 cases in each group. The control group was given comprehensive treatment while the observation group was treated with HGG. The time of disappearance of clinical signs and symptoms, time of improvement of pulmonary iconography, inflammatory indices, time and degree of improvement of lung function and adverse reactions were observed. The total effective rate in the observation group was 97.5% and significantly higher than control group (77.5%). The time of fever clearance, imaging improvement as well as cough and pulmonary rales disappearance in the observation group was shorter than control group. After treatment, the levels of inflammatory indicators such as erythrocyte sedimentation rate (ESR) and C-reaction protein (CRP) in the observation group were lower than control group. No obvious abnormalities of urea nitrogen, creatinine, serum alanine amino transferase (ALT) and aspartate amino transferase (AST) were found in the two groups. Overall, HGG effectively shortened the course of RMPP, improved the cure rate, reduced the inflammatory reaction and promoted the recovery of lung function without obvious adverse reaction.
本研究的主要目的是探讨人丙种球蛋白(HGG)对儿童炎症指标的影响。总共80名儿童被随机分为观察组和对照组,每组40例。对照组给予综合治疗,而观察组则用HGG治疗。观察临床体征和症状消失时间、肺部影像学改善时间、炎症指标、肺功能改善时间和程度以及不良反应。观察组的总有效率为97.5%,显著高于对照组(77.5%)。观察组的退热时间、影像学改善以及咳嗽和肺部啰音消失时间均短于对照组。治疗后,观察组的红细胞沉降率(ESR)和C反应蛋白(CRP)等炎症指标水平低于对照组。两组均未发现尿素氮、肌酐、血清丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)有明显异常。总体而言,HGG有效缩短了难治性支原体肺炎(RMPP)的病程,提高了治愈率,减轻了炎症反应,促进了肺功能恢复,且无明显不良反应。