Lu Yinhui, Yin Juan, Wu Xiaohe, Fan Yuqin, Liu Fenfen
Department of Gerontology, Jiangxi Provincial People's Hospital, Nanchang, PR China.
Pak J Pharm Sci. 2019 Sep;32(5(Special)):2433-2436.
This study was designed to compare the efficacy of two different racemic antihypertensive drugs on elderly patients with hypertension and their effects on vascular endothelial function and atherosclerosis. A total of 84 elderly hypertensive patients were randomly divided into control and treatment group with 42 patients in each group. The control group was treated with 2.5mg levamlodipine while the treatment group was given 5mg amlodipine. Total effective rate of the treatment group was 90.5%, higher than the control group, that was 71.4% (P<0.05). The time for recovery of related indicators like blood pressure, the total duration of medication were significantly (P<0.05) shorter in the treatment group. Only 1 case of adverse drug reaction was found in the treatment group while 6 cases in control group. Compared to the control group, the treatment group had massive improvement in fingertip pulse volume, flow-mediated dilation of the brachial arteries and endothelin-1 level, carotid intima-media thickness, plaque length & thickness, and blood pressure after the administration. The rate of satisfaction with the in treatment group was 95.3%, higher than that the control group, which was 78.6%. The study concluded that in elderly patients with hypertension, the treatment with 5mg amlodipine enhanced curative effect, fully improved endothelial function & arteriosclerosis and reduced adverse reactions thereby shortening treatment time.
本研究旨在比较两种不同的消旋抗高血压药物对老年高血压患者的疗效及其对血管内皮功能和动脉粥样硬化的影响。总共84例老年高血压患者被随机分为对照组和治疗组，每组42例。对照组给予2.5mg左旋氨氯地平治疗，治疗组给予5mg氨氯地平。治疗组总有效率为90.5%，高于对照组的71.4%（P<0.05）。治疗组血压等相关指标恢复时间、用药总时长显著缩短（P<0.05）。治疗组仅发现1例药物不良反应，而对照组有6例。与对照组相比，治疗组给药后指尖脉搏容积、肱动脉血流介导的扩张和内皮素-1水平、颈动脉内膜中层厚度、斑块长度和厚度以及血压有大幅改善。治疗组的满意度为95.3%，高于对照组的78.6%。研究得出结论，在老年高血压患者中，5mg氨氯地平治疗可提高疗效，充分改善内皮功能和动脉硬化，减少不良反应，从而缩短治疗时间。
