溶剂控制的炔酮和（异）喹啉 N-氧化物的发散环化反应：3-（（异）喹啉-1-基）-4H-色烯-4-酮和 13H-异喹啉并[2,1-a]喹啉-13-酮。
Solvent-controlled divergent annulation of ynones and (iso)quinoline N-oxides: of 3-((iso)quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino[2,1-a]quinolin-13-ones.
机构信息
Institute of Functional Organic Molecular Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China.
出版信息
Chem Commun (Camb). 2020 Jan 28;56(8):1183-1186. doi: 10.1039/c9cc08713c.
An effective annulation of ynones and (iso)quinoline N-oxides was developed to deliver various functionalized 3-((iso)quinolin-1-yl)-4H-chromen-4-ones and 13H-isoquinolino[2,1-a]quinolin-13-ones in moderate to excellent yields, respectively. This protocol exhibits high regioselectivity and broad substrate scope under transition-metal-free conditions. Moreover, the key reaction intermediate was successfully isolated and determined unambiguously by single crystal X-ray crystallography.
发展了一种有效的 ynones 和（异）喹啉 N-氧化物的环化反应，分别以中等到优秀的收率得到了各种功能化的 3-((异)喹啉-1-基)-4H-色烯-4-ones 和 13H-异喹啉[2,1-a]喹啉-13-ones。该反应在无过渡金属条件下具有高区域选择性和广泛的底物范围。此外，通过单晶 X 射线晶体学成功地分离和明确确定了关键反应中间体。
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