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用于指尖截肢的复合移植物:一项系统评价方案

Composite grafts for fingertip amputations: A systematic review protocol.

作者信息

Borrelli Mimi R, Landin Madeleine L, Agha Riaz, Greig Aina

机构信息

Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic Surgery, Stanford University School of Medicine, Stanford, CA, United States.

King's College London, Guy's, King's and St Thomas' School of Medicine, Guy's Campus, Great Maze Pond, London SE1 9RT, United Kingdom.

出版信息

Int J Surg Protoc. 2019 May 23;16:1-4. doi: 10.1016/j.isjp.2019.05.001. eCollection 2019.

Abstract

BACKGROUND

There is much debate in the hand surgery literature as to the management of fingertip amputations. Much research continues to be published in this area. Methods of reattachment include microsurgical and non-microsurgical (composite graft) replantation. The role of composite grafts lacks clarity in terms of outcomes, success rates and complications. Hence there is a need for an evidence synthesis, which can guide patient selection, the consent process and determine graft survival rates and functional outcomes to optimise patient outcomes.

METHODS

Search of the databases OVID MEDLINE, PubMed, EMBASE, SCOPUS, The Cochrane Library and clinical trial registries from inception using terms "fingertip" "digital tip" "digit" "finger" "thumb" "amputation" "replantation" "reattachment" "reimplantation" and "composite graft" as key terms with "AND" selected as a Boolean operator, limited to humans will be conducted by two independent researchers. The patient population will include adults and children. Studies will be included if they report: (1) primary data; (2) outcomes of 'composite grafts' or 'nonmicrosurgical replantations'; (3) graft survival, (4) 5 or more cases. Articles will be excluded if surgical techniques involve: (1) composite graft pocketing, or (2) microsurgical replantation or (3) additional flaps (pulp or local). Full exclusion and inclusion criteria are described within this protocol. Data extraction will include; demographic details, patient comorbidities, amputation nature and level, functional, and aesthetic outcomes, complications and need for secondary procedures. All data extracted will be cross-checked, and discrepancies resolved through consensus.

DISSEMINATION

This review will be published in a peer-reviewed journal and will be presented at national and international conferences to inform the practice of other clinicians.

摘要

背景

在手外科文献中,关于指尖离断伤的处理存在诸多争议。该领域仍有大量研究不断发表。再植方法包括显微外科和非显微外科(复合组织移植)再植。复合组织移植在疗效、成功率及并发症方面的作用尚不明确。因此,需要进行证据综合分析,以指导患者选择、知情同意过程,并确定移植成活率和功能结局,从而优化患者预后。

方法

两名独立研究人员将从数据库OVID MEDLINE、PubMed、EMBASE、SCOPUS、Cochrane图书馆及临床试验注册库自建库起进行检索,使用“指尖”“指端”“手指”“拇指”“离断伤”“再植”“重新附着”“再植入”和“复合组织移植”等术语作为关键词,并选择“AND”作为布尔运算符,检索限于人类研究。患者群体将包括成人和儿童。若研究报告以下内容,则纳入研究:(1)原始数据;(2)“复合组织移植”或“非显微外科再植”的结局;(3)移植成活率;(4)5例或更多病例。若手术技术涉及以下内容,则排除文章:(1)复合组织移植袋状植入;(2)显微外科再植;(3)额外皮瓣(指腹或局部皮瓣)。本方案中描述了完整的排除和纳入标准。数据提取将包括:人口统计学细节、患者合并症、离断伤性质和水平、功能及美学结局、并发症以及二次手术需求。所有提取的数据将进行交叉核对,差异通过协商解决。

传播

本综述将发表在同行评审期刊上,并将在国内和国际会议上展示,以为其他临床医生的实践提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bad/6921220/b81864727c4d/gr1.jpg

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