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Pronounced influence of presystemic metabolism on the metabolic disposition of imrecoxib in renally impaired patients.

作者信息

Srinivas Nuggehally R

机构信息

Department of Innovation and Technology, Jubilant Life Sciences, Sector 59 (D-10), Noida, Uttar Pradesh, India.

Kenox Pharmaceuticals Inc, 11 Deerpark Dr, Suite 128, Princeton Corporate Plaza, Monmouth Junction, NJ, 08852, USA.

出版信息

Eur J Clin Pharmacol. 2020 Mar;76(3):469-471. doi: 10.1007/s00228-019-02824-9. Epub 2020 Jan 3.

DOI:10.1007/s00228-019-02824-9
PMID:31897535
Abstract
摘要

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本文引用的文献

1
Pharmacokinetic study of imrecoxib in patients with renal insufficiency.肾功能不全患者伊米昔布的药代动力学研究。
Eur J Clin Pharmacol. 2019 Oct;75(10):1355-1360. doi: 10.1007/s00228-019-02698-x. Epub 2019 Jun 27.
2
Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies - Review of Case Studies.鸡尾酒探针药物在临床药理学研究中用于细胞色素P450酶指标测定——病例研究综述
Drug Metab Lett. 2019;13(1):3-18. doi: 10.2174/1872312812666181119154734.
3
Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate.
在体和体外人类伊米考昔代谢的差异：限速醛中间产物的形成。
Drug Metab Dispos. 2018 Sep;46(9):1320-1328. doi: 10.1124/dmd.118.081182. Epub 2018 Jul 6.
4
The Role of the Kidney in Drug Elimination: Transport, Metabolism, and the Impact of Kidney Disease on Drug Clearance.肾脏在药物消除中的作用：转运、代谢以及肾脏疾病对药物清除的影响。
Clin Pharmacol Ther. 2017 Sep;102(3):436-449. doi: 10.1002/cpt.757. Epub 2017 Jul 26.
5
Consequences of renal failure on non-renal clearance of drugs.肾衰竭对药物非肾清除的影响。
Clin Pharmacokinet. 2014 Jun;53(6):521-32. doi: 10.1007/s40262-014-0146-1.
6
Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport.慢性肾脏病和尿毒症对肝脏药物代谢及转运的影响。
Kidney Int. 2014 Mar;85(3):522-8. doi: 10.1038/ki.2013.399. Epub 2013 Oct 16.
7
The effects of acute renal failure on drug metabolism.急性肾衰竭对药物代谢的影响。
Expert Opin Drug Metab Toxicol. 2014 Jan;10(1):11-23. doi: 10.1517/17425255.2013.835802. Epub 2013 Sep 28.
8
Altered disposition of drugs in acute renal failure rat models: drug development strategies and perspectives.急性肾衰竭大鼠模型中药物处置的改变：药物研发策略与展望
Arzneimittelforschung. 2010;60(12):731-48. doi: 10.1055/s-0031-1296349.
9
Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib.艾瑞昔布主要代谢产物的合成及其抗炎活性
Bioorg Med Chem Lett. 2009 Apr 15;19(8):2270-2. doi: 10.1016/j.bmcl.2009.02.090. Epub 2009 Feb 27.
10
Metabolism and excretion of imrecoxib in rat.艾瑞昔布在大鼠体内的代谢与排泄
Xenobiotica. 2006 May;36(5):441-55. doi: 10.1080/00498250600595524.