Department of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University, 1780, Gobara, Hirooka, Shiojiri, Nagano, 399-0781, Japan.
Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
J Bone Miner Metab. 2020 May;38(3):357-362. doi: 10.1007/s00774-019-01063-3. Epub 2020 Jan 2.
Fragility fractures can cause delayed wound healing after tooth extraction, which contributes to an increased risk of osteomyelitis of the jaw. We evaluated whether a history of fragility fracture was associated with increased risk of delayed wound healing after tooth extraction in older adults in Japan.
Of 5352 people aged 50-89 years in the 2014 basic resident registry of the town of Obuse, the present study included 376 subjects (190 men and 186 women) who completed a structured questionnaire and measurement of the bone mineral densities (BMDs) of the bilateral femoral neck. Delayed wound healing after tooth extraction was self-reported. Fragility fractures were confirmed via examination of hospital medical records. Logistic regression analyses adjusted for age and gender were used to evaluate association of clinical variables with delayed would healing after tooth extractions. Odds ratios (ORs) and the 95% confidence intervals (CIs) of all possible associated variables for the presence of delayed wound healing were calculated.
Subjects with a history of fragility fractures had a significantly higher risk of delayed wound healing compared with those without previous fragility fractures (OR 2.68; 95% CI 1.11-6.46, p = 0.028). This association still remained after adjusted for all other variables (OR 2.70; 95% CI 1.10-6.60, p = 0.030). Delayed wound healing was not significantly associated with the BMD of the femoral neck.
History of fragility fracture may be associated with increased risk of delayed wound healing after tooth extraction in Japanese men and women aged 50-89 years.
脆性骨折可导致拔牙后伤口愈合延迟，从而增加下颌骨髓炎的风险。我们评估了在日本老年人中，脆性骨折史是否与拔牙后伤口愈合延迟的风险增加相关。
在 5352 名年龄在 50-89 岁的小布施镇 2014 年基本居民登记册中，本研究纳入了 376 名受试者（190 名男性和 186 名女性），他们完成了一份结构化问卷，并测量了双侧股骨颈的骨密度（BMD）。拔牙后伤口愈合延迟情况通过检查医院病历来确认。使用逻辑回归分析调整年龄和性别因素，评估临床变量与拔牙后伤口愈合延迟的关系。计算所有可能与拔牙后伤口愈合延迟相关的变量的比值比（OR）及其 95%置信区间（CI）。
与无既往脆性骨折史的受试者相比，有脆性骨折史的受试者拔牙后伤口愈合延迟的风险显著更高（OR 2.68；95%CI 1.11-6.46，p=0.028）。在调整了所有其他变量后，这种关联仍然存在（OR 2.70；95%CI 1.10-6.60，p=0.030）。股骨颈 BMD 与拔牙后伤口愈合延迟无显著相关性。
脆性骨折史可能与 50-89 岁日本男性和女性拔牙后伤口愈合延迟的风险增加相关。
