颅底侵袭性腺样囊性癌的治疗管理：当代综述。
Management of advanced adenoid cystic carcinoma infiltrating the skull base: a contemporary review.
机构信息
Queensland Skull Base Unit, Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.
出版信息
J Neurooncol. 2020 Dec;150(3):419-427. doi: 10.1007/s11060-019-03366-x. Epub 2020 Jan 2.
INTRODUCTION
This article provides an overview of the natural history and management of adenoid cystic carcinoma infiltrating the skull base (SB ACC).
METHODS
A comprehensive review of the available literature and discussion regarding the current management of SB ACC.
RESULTS
This review describes the unique pathology, appropriate diagnostic work-up and contemporary management options in SB ACC. There is a specific focus on the role of surgical resection with post-operative radiotherapy, given the literature suggesting a superior locoregional control rate. The importance of surgical decision making and varying surgical approaches are detailed. In addition, the emerging role of biological agents is discussed.
CONCLUSION
The gold standard for SB ACC is surgical resection and post-operative radiation, given the superior locoregional control. In patients not amendable to surgery, palliative radiation should be considered. The role of biological agents is still evolving. The complexity of SB ACC management mandates experienced multi-speciality management.
简介
本文概述了累及颅底的腺样囊性癌（SB ACC）的自然病程和治疗管理。
方法
对现有文献进行全面复习，并就 SB ACC 的当前治疗管理进行讨论。
结果
本综述描述了 SB ACC 独特的病理学、合适的诊断性检查和当代治疗管理选择，特别关注了手术切除加术后放疗的作用，因为文献表明这种治疗方法在局部区域控制方面有更好的效果。手术决策和不同手术入路的重要性也有详细描述。此外，还讨论了生物制剂的新作用。
结论
鉴于 SB ACC 局部区域控制效果更好，手术切除加术后放疗是 SB ACC 的金标准。对于不适合手术的患者，应考虑姑息性放疗。生物制剂的作用仍在不断发展。SB ACC 治疗管理的复杂性需要经验丰富的多学科管理。
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