Alphin R S, Droppleman D A
Eur J Pharmacol. 1977 Jan 21;41(2):235-7. doi: 10.1016/0014-2999(77)90216-3.
The role of pepsin proteolytic activity in the Exalto-Mann-Williamson ulcer has previously not been established. Our studies show that a potent inhibitor of pepsin activity, when administered orally to E-M-W dogs, reduced both the incidence and severity of jejunal ulceration. These results indicate that pepsin may play a major role in the development of ulceration in this model.
胃蛋白酶的蛋白水解活性在埃克塞尔托-曼-威廉姆森溃疡中所起的作用此前尚未明确。我们的研究表明，一种强效胃蛋白酶活性抑制剂经口服给予埃克塞尔托-曼-威廉姆森犬后，空肠溃疡的发生率和严重程度均有所降低。这些结果表明，在该模型中胃蛋白酶可能在溃疡形成过程中起主要作用。
