Lin Jing, Chen Zhimin
The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019 Jul 25;48(5):567-572. doi: 10.3785/j.issn.1008-9292.2019.10.16.
Severe adenovirus pneumonia has a high mortality and incidence of sequelae. Fever and cough are the main symptoms of children's severe adenovirus pneumonia, but such clinical manifestations are lack of specificity. For children with persistent high fever who are in the epidemic age and season, the adenovirus etiology detection, blood routine, cytokines, T cell subsets and imaging examinations are suggested. Children with early manifestations of infiltration of lung segment and lobar parenchyma, obvious emphysema, interstitial pneumonia or a large amount of pleural effusion should be alerted to have severe adenovirus pneumonia. This article reviews the epidemiological characteristics and risk factors of adenovirus pneumonia in different seasons, regions and serology, and the laboratory findings and imaging features of severe adenovirus pneumonia, which would be helpful for the early identification of the disease.
重症腺病毒肺炎死亡率高，后遗症发生率也高。发热和咳嗽是儿童重症腺病毒肺炎的主要症状，但这些临床表现缺乏特异性。对于处于流行年龄和季节且持续高热的儿童，建议进行腺病毒病原学检测、血常规、细胞因子、T细胞亚群及影像学检查。对于早期出现肺段和肺叶实质浸润、明显肺气肿、间质性肺炎或大量胸腔积液表现的儿童，应警惕重症腺病毒肺炎。本文综述了不同季节、地区和血清型腺病毒肺炎的流行病学特征及危险因素，以及重症腺病毒肺炎的实验室检查结果和影像学特征，这将有助于该病的早期识别。
