• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Data From the World Health Organization's Pharmacovigilance Database Supports the Prominent Role of Pneumonia in Mortality Associated With Clozapine Adverse Drug Reactions.

作者信息

De Leon Jose, Sanz Emilio J, De Las Cuevas Carlos

机构信息

Mental Health Research Center at Eastern State Hospital, Lexington, KY.

Department of Physical Medicine and Pharmacology, School of Medicine, Universidad de La Laguna, Canary Islands, Spain.

出版信息

Schizophr Bull. 2020 Jan 4;46(1):1-3. doi: 10.1093/schbul/sbz093.

DOI:10.1093/schbul/sbz093
PMID:31901099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6942151/
Abstract
摘要

相似文献

1
Data From the World Health Organization's Pharmacovigilance Database Supports the Prominent Role of Pneumonia in Mortality Associated With Clozapine Adverse Drug Reactions.世界卫生组织药物警戒数据库的数据支持肺炎在氯氮平药物不良反应相关死亡率中起显著作用。
Schizophr Bull. 2020 Jan 4;46(1):1-3. doi: 10.1093/schbul/sbz093.
2
Adverse drug reactions and their fatal outcomes in clozapine patients in VigiBase: Comparing the top four reporting countries (US, UK, Canada and Australia).维格列数据库中氯氮平患者的药物不良反应及其致死结局：比较前四位报告国家（美国、英国、加拿大和澳大利亚）。
Schizophr Res. 2024 Jun;268:165-174. doi: 10.1016/j.schres.2023.05.004. Epub 2023 Jun 9.
3
Clozapine-associated myocarditis in the World Health Organization's pharmacovigilance database: Focus on reports from various countries.世界卫生组织药物警戒数据库中氯氮平相关心肌炎：聚焦各国报告
Rev Psiquiatr Salud Ment (Engl Ed). 2022 Oct-Dec;15(4):238-250. doi: 10.1016/j.rpsmen.2021.07.005.
4
An expert review of clozapine in Latin American countries: Use, monitoring, and pharmacovigilance.《拉丁美洲国家氯氮平的专家综述：使用、监测和药物警戒》
Schizophr Res. 2024 Jun;268:60-65. doi: 10.1016/j.schres.2023.10.025. Epub 2023 Nov 18.
5
Risk of appendicitis associated with the use of clozapine: A pharmacovigilance study.使用氯氮平与阑尾炎风险的关联：一项药物警戒研究。
Asian J Psychiatr. 2022 Nov;77:103264. doi: 10.1016/j.ajp.2022.103264. Epub 2022 Sep 15.
6
According to the WHO clozapine pharmacovigilance database, the United Kingdom accounts for 968 fatal outcomes versus 892 in the rest of the world.根据世界卫生组织氯氮平药物警戒数据库，英国有968例死亡病例，而世界其他地区有892例。
Br J Clin Pharmacol. 2022 Dec;88(12):5434-5435. doi: 10.1111/bcp.15522. Epub 2022 Sep 15.
7
Association between myocarditis and antipsychotics other than clozapine: a systematic literature review and a pharmacovigilance study using VigiBase.心肌炎与氯氮平以外的抗精神病药物之间的关联：一项系统文献综述及使用药物警戒数据库（VigiBase）的药物警戒研究
Expert Rev Clin Pharmacol. 2022 Jan;15(1):65-78. doi: 10.1080/17512433.2022.2032659. Epub 2022 Jan 27.
8
Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK.揭示报告差异：VigiBase 突出显示与英国相比，其他西欧国家氯氮平报告不足。
Schizophr Res. 2024 Jun;268:175-188. doi: 10.1016/j.schres.2023.11.010. Epub 2023 Dec 7.
9
Escaping the Long Shadow Cast by Agranulocytosis: Reflections on Clozapine Pharmacovigilance Focused on the United Kingdom.摆脱粒细胞缺乏症的长期阴影：关于以英国为重点的氯氮平药物警戒的思考
J Clin Psychopharmacol. 2023;43(3):239-245. doi: 10.1097/JCP.0000000000001678.
10
Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study.国际药物警戒中抗精神病药物与心肌疾病：数据挖掘研究
BMJ. 2001 May 19;322(7296):1207-9. doi: 10.1136/bmj.322.7296.1207.

引用本文的文献

1
Pre- and Post- COVID-19 Pandemic Pneumonia Rates in Hospitalized Schizophrenia Patients.新冠疫情前后住院精神分裂症患者的肺炎发生率
Medicina (Kaunas). 2025 Jul 10;61(7):1251. doi: 10.3390/medicina61071251.
2
Elevated neutrophil-to-lymphocyte ratios correlate with increased clozapine concentration-to-dose ratios during titration.在滴定过程中，中性粒细胞与淋巴细胞比值升高与氯氮平血药浓度-剂量比值增加相关。
Schizophrenia (Heidelb). 2025 Jul 10;11(1):96. doi: 10.1038/s41537-025-00648-4.
3
Higher clozapine concentration-to-dose ratios at week 1 after initiation are associated with increased risk of clozapine-associated fever in Japanese patients with schizophrenia.在日本精神分裂症患者中，起始治疗后第1周较高的氯氮平浓度-剂量比与氯氮平相关发热风险增加有关。
Front Psychiatry. 2025 May 30;16:1591568. doi: 10.3389/fpsyt.2025.1591568. eCollection 2025.
4
Signal detection of ferric carboxymaltose-induced serious adverse events: disproportionality analysis of FAERS and VigiBase data and systematic review of case reports.羧基麦芽糖铁诱导严重不良事件的信号检测：FAERS和VigiBase数据的不成比例分析及病例报告的系统评价
Eur J Clin Pharmacol. 2025 May 22. doi: 10.1007/s00228-025-03849-z.
5
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I: A Review of the Pharmacokinetic Literature and Proposed Changes.致美国食品药品监督管理局的信：提议对美国氯氮平药品说明书进行重大修改，全球氯氮平专家提供支持。第一部分：药代动力学文献综述及提议的修改内容。
J Clin Psychopharmacol. 2025;45(3):179-196. doi: 10.1097/JCP.0000000000001987. Epub 2025 Apr 9.
6
Beyond Acute Overdoses: A Case of Chronic Clozapine Toxicity With Non-specific Presentation.超越急性过量：一例表现不典型的氯氮平慢性中毒病例
Cureus. 2025 Feb 27;17(2):e79771. doi: 10.7759/cureus.79771. eCollection 2025 Feb.
7
Clozapine and Pneumonia: Synthesizing the Link by Reviewing Existing Reports-A Systematic Review and Meta-Analysis.氯氮平与肺炎：通过综述现有报告综合两者联系——一项系统评价与荟萃分析
Medicina (Kaunas). 2024 Dec 6;60(12):2016. doi: 10.3390/medicina60122016.
8
Effect of Organic Anion Transporting Polypeptide 1B1 on Plasma Concentration Dynamics of Clozapine in Patients with Treatment-Resistant Schizophrenia.有机阴离子转运多肽1B1对难治性精神分裂症患者氯氮平血药浓度动态的影响
Int J Mol Sci. 2024 Dec 9;25(23):13228. doi: 10.3390/ijms252313228.
9
Evaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data.评估儿童和青少年人群中氯氮平的药物不良反应：来自药物不良反应数据库（VigiBase）数据的见解
Eur Child Adolesc Psychiatry. 2024 Dec 2. doi: 10.1007/s00787-024-02623-3.
10
Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia.NMDA 受体功能障碍在精神分裂症病理生理学和/或治疗抵抗性精神分裂症发病机制中的作用。
Biomolecules. 2024 Sep 6;14(9):1128. doi: 10.3390/biom14091128.

本文引用的文献

1
Pneumonia may be more frequent and have more fatal outcomes with clozapine than with other second-generation antipsychotics.与其他第二代抗精神病药物相比，使用氯氮平治疗时肺炎可能更常见，且致死率更高。
World Psychiatry. 2020 Feb;19(1):120-121. doi: 10.1002/wps.20707.
2
A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults.成人抗精神病药物相关吞咽困难和吞咽障碍的综合综述。
Expert Rev Clin Pharmacol. 2019 Mar;12(3):219-234. doi: 10.1080/17512433.2019.1577134. Epub 2019 Feb 8.
3
Clozapine and Long-Term Mortality Risk in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Studies Lasting 1.1-12.5 Years.氯氮平与精神分裂症患者的长期死亡风险：持续 1.1-12.5 年的研究的系统评价和荟萃分析。
Schizophr Bull. 2019 Mar 7;45(2):315-329. doi: 10.1093/schbul/sby052.
4
Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report.严重呼吸道感染可使氯氮平水平升高并导致副作用：一例病例报告。
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):1059-63. doi: 10.1016/S0278-5846(03)00148-9.