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Elevated neutrophil-to-lymphocyte ratios correlate with increased clozapine concentration-to-dose ratios during titration.在滴定过程中，中性粒细胞与淋巴细胞比值升高与氯氮平血药浓度-剂量比值增加相关。
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Higher clozapine concentration-to-dose ratios at week 1 after initiation are associated with increased risk of clozapine-associated fever in Japanese patients with schizophrenia.在日本精神分裂症患者中，起始治疗后第1周较高的氯氮平浓度-剂量比与氯氮平相关发热风险增加有关。
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Effect of Organic Anion Transporting Polypeptide 1B1 on Plasma Concentration Dynamics of Clozapine in Patients with Treatment-Resistant Schizophrenia.有机阴离子转运多肽1B1对难治性精神分裂症患者氯氮平血药浓度动态的影响
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Eur Child Adolesc Psychiatry. 2024 Dec 2. doi: 10.1007/s00787-024-02623-3.
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Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia.NMDA 受体功能障碍在精神分裂症病理生理学和/或治疗抵抗性精神分裂症发病机制中的作用。
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本文引用的文献

1
Pneumonia may be more frequent and have more fatal outcomes with clozapine than with other second-generation antipsychotics.与其他第二代抗精神病药物相比，使用氯氮平治疗时肺炎可能更常见，且致死率更高。
World Psychiatry. 2020 Feb;19(1):120-121. doi: 10.1002/wps.20707.
2
A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults.成人抗精神病药物相关吞咽困难和吞咽障碍的综合综述。
Expert Rev Clin Pharmacol. 2019 Mar;12(3):219-234. doi: 10.1080/17512433.2019.1577134. Epub 2019 Feb 8.
3
Clozapine and Long-Term Mortality Risk in Patients With Schizophrenia: A Systematic Review and Meta-analysis of Studies Lasting 1.1-12.5 Years.氯氮平与精神分裂症患者的长期死亡风险：持续 1.1-12.5 年的研究的系统评价和荟萃分析。
Schizophr Bull. 2019 Mar 7;45(2):315-329. doi: 10.1093/schbul/sby052.
4
Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report.严重呼吸道感染可使氯氮平水平升高并导致副作用：一例病例报告。
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):1059-63. doi: 10.1016/S0278-5846(03)00148-9.

Data From the World Health Organization's Pharmacovigilance Database Supports the Prominent Role of Pneumonia in Mortality Associated With Clozapine Adverse Drug Reactions.

作者信息

De Leon Jose, Sanz Emilio J, De Las Cuevas Carlos

机构信息

Mental Health Research Center at Eastern State Hospital, Lexington, KY.

Department of Physical Medicine and Pharmacology, School of Medicine, Universidad de La Laguna, Canary Islands, Spain.

出版信息

Schizophr Bull. 2020 Jan 4;46(1):1-3. doi: 10.1093/schbul/sbz093.

DOI:10.1093/schbul/sbz093
PMID:31901099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6942151/
Abstract
摘要