Güler Kazancı Elif, Korkmaz Muhammet Furkan, Can Mehmet Erol
Department of Pediatric Hematology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Department of Pediatrics, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Eur J Ophthalmol. 2020 May;30(3):600-607. doi: 10.1177/1120672119899375. Epub 2020 Jan 5.
The purpose was to evaluate retinal vascular parameters by optical coherence tomography angiography in β-thalassemia major patients.
Thirty-three patients with β-thalassemia major (study group) and 29 healthy children (control group) were enrolled in the study. All subjects underwent a complete ocular examination. The mean foveal avascular zone, non-flow area, foveal avascular zone perimeter, acircularity index of foveal avascular zone, foveal density, the superficial capillary plexus, and deep capillary plexus were scanned using 6 × 6 mm optical coherence tomography angiography scans centered on the macula. Superficial capillary plexus and deep capillary plexus were also scanned centered on the optic disk. We collected data on histories of patients, and hemoglobin and ferritin were also studied from both groups.
The mean age was 13.85 ± 4.69 years (range: 4-21 years) in β-thalassemia major group and 12.59 ± 3.66 years (range: 6-18 years) in the control group. The mean foveal avascular zone value was 0.265 ± 0.11 mm in the study group and 0.296 ± 0.12 mm in the control group. The mean non-flow area value was 0.468 ± 0.12 mm in the study group and 0.479 ± 0.14 mm in the control group ( > 0.05). Differences in the mean values for foveal density and acircularity index were statistically significant between the study group and control group ( < 0.05, = 0.026, and = 0.026, respectively). Superficial capillary plexus and deep capillary plexus were not a significant difference between the study and control groups in 6 × 6 mm scans on macula and 4.5 × 4.5 mm scans on optic disk area ( > 0.05). Acircularity index was negatively correlated ( = -0.292, = 0.026), and foveal density was positively correlated with hemoglobin ( = 0.292, = 0.026).
By using optical coherence tomography angiography, we detected foveal microvascular changes in young β-thalassemia patients before significant ocular anomalies development.
本研究旨在通过光学相干断层扫描血管造影术评估重型β地中海贫血患者的视网膜血管参数。
本研究纳入了33例重型β地中海贫血患者（研究组）和29例健康儿童（对照组）。所有受试者均接受了全面的眼部检查。使用以黄斑为中心的6×6mm光学相干断层扫描血管造影术扫描平均中心凹无血管区、非血流区、中心凹无血管区周长、中心凹无血管区的非圆度指数、中心凹密度、浅表毛细血管丛和深部毛细血管丛。还以视盘为中心扫描了浅表毛细血管丛和深部毛细血管丛。我们收集了患者的病史数据，并对两组患者的血红蛋白和铁蛋白进行了研究。
重型β地中海贫血组的平均年龄为13.85±4.69岁（范围：4 - 21岁），对照组的平均年龄为12.59±3.66岁（范围：6 - 18岁）。研究组的平均中心凹无血管区值为0.265±0.11mm，对照组为0.296±0.12mm。研究组的平均非血流区值为0.468±0.12mm，对照组为0.479±0.14mm（>0.05）。研究组和对照组之间中心凹密度和非圆度指数的平均值差异具有统计学意义（分别为<0.05、=0.026和=0.026）。在黄斑区6×6mm扫描和视盘区4.5×4.5mm扫描中浅表毛细血管丛和深部毛细血管丛在研究组和对照组之间无显著差异（>0.05）。非圆度指数呈负相关（=-0.292，=0.026），中心凹密度与血红蛋白呈正相关（=0.292，=0.026）。
通过使用光学相干断层扫描血管造影术，我们在年轻的重型β地中海贫血患者出现明显眼部异常之前检测到了中心凹微血管变化。
