Kessler H A, Benson C A, Urbanski P
Department of Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612.
Arch Intern Med. 1988 Nov;148(11):2496-7.
We describe two patients with human immunodeficiency virus infection and oral hairy leukoplakia whose tongue lesions resolved on oral zidovudine therapy. During therapy, each patient had a measurable reduction in human immunodeficiency virus antigen corresponding with clinical regression of oral lesions. The clinical course suggests that zidovudine may have contributed to the resolution of these lesions either indirectly through immunologic improvement or through an antiviral effect.
我们描述了两名感染人类免疫缺陷病毒且患有口腔毛状白斑的患者，他们的舌头病变在接受口服齐多夫定治疗后消退。在治疗期间，每名患者体内的人类免疫缺陷病毒抗原都有可测量的减少，这与口腔病变的临床消退相对应。临床病程表明，齐多夫定可能通过免疫功能改善间接促成了这些病变的消退，或者是通过抗病毒作用。
