Department of Physics, Babol Noshirvani University of Technology, Babol, Iran.
Department of Physics, University of Ottawa, Ottawa, ON, Canada.
Int J Neurosci. 2020 Sep;130(9):917-925. doi: 10.1080/00207454.2019.1709843. Epub 2020 Jan 12.
In this article, we propose current source density (CSD) as a marker for diagnosis of Attention Deficit and Hyperactivity Disorder (ADHD) children for the first time. A source localization method (sLORETA) was used to find the source of abnormality in the CSD in electrical distribution of different frequency bands in resting state EEG for the ADHD children in comparison to the normal children using statistical nonparametric mapping (SnPM) test. Resting-state EEG in eye-open (EO) condition was recorded from 13 ADHD and 15 age-matched normal children (aged between 6 and 13). Significant differences were found in the CSD of three frequency bands: delta, theta, and alpha in the parietal lobe, between ADHD and normal groups. Higher CSD in the parietal lobe for ADHD children was found which suggests that an abnormality exists in the parietal lobe of children with ADHD which can be related to the attention shifting problem in these children.
本文首次提出电流源密度（CSD）可作为诊断注意缺陷多动障碍（ADHD）儿童的标志物。我们使用源定位方法（sLORETA），通过统计非参数映射（SnPM）检验，比较 ADHD 儿童和正常儿童在静息状态脑电图不同频段的电分布中 CSD 的异常源，发现 ADHD 儿童静息状态脑电图在睁眼（EO）条件下，与正常儿童相比，在顶叶有三个频带（δ、θ 和α）的 CSD 存在显著差异。ADHD 儿童顶叶的 CSD 更高，这表明 ADHD 儿童的顶叶存在异常，这可能与这些儿童的注意力转移问题有关。
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