Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Org Biomol Chem. 2020 Jan 28;18(4):694-699. doi: 10.1039/c9ob02234a. Epub 2020 Jan 6.
Heterotopic tri-cationic receptors based on 4,10,16-triaza-18-crown-6 are capable of efficient and selective binding of the zwitterionic form of 5-aminovaleric acid (5-AVA) in aqueous/methanol solution. The cooperative participation of both cation and anion binding domains of this receptor in 5-AVA complexation was established by H NMR experiments and DFT calculations. Heterotopic receptors and fluorescein were used for the preparation of indicator displacement assay and this assembly was applied to selective optical sensing of 5-aminovaleric acid.
基于 4,10,16-三氮杂-18-冠-6 的杂合三阳离子受体能够在水/甲醇溶液中有效且选择性地结合两性离子形式的 5-氨基戊酸（5-AVA）。通过 NMR 实验和 DFT 计算证实了该受体的阳离子和阴离子结合域在 5-AVA 络合中的协同参与。杂合受体和荧光素被用于制备指示剂置换测定法，该组装体被用于选择性光学检测 5-氨基戊酸。
