Aurin Johanna, Thorlacius Henrik, Butt Salma Tunå
Institution of Clinical Sciences Malmö, Department of Surgery, Skåne University Hospital Malmo, Lund University, 205 02, Malmö, Sweden.
BMC Res Notes. 2020 Jan 6;13(1):9. doi: 10.1186/s13104-019-4864-1.
Late age at first childbirth is a well-established risk factor for breast cancer. Previous studies have, however, shown conflicting results to whether late age at first childbirth also influences the prognosis of breast cancer survival. The aim of this study was to examine age at first birth in relation to survival after breast cancer diagnosis.
We used information from the Malmö Diet and Cancer study. At baseline 17,035 women were included. All women were followed from the year they developed breast cancer until they either died or until the end of follow-up. All women were asked how many children they had given birth to and were then divided into different groups, ≤ 20, > 20 to ≤ 25, > 25 to ≤ 30 and > 30. Nulliparous women form a separate group. Survival analyses were then performed using Cox proportional hazard survival analysis. Women in all age groups had a lower risk of breast cancer specific death as compared to the reference group ≤ 20, however non-significantly. Nulliparous women had a higher risk of breast cancer specific death as compared to the same reference group, however these results were not statistically significant. We could not see any negative effect of late first childbirth on breast cancer specific survival.
高龄初产是公认的乳腺癌危险因素。然而，先前的研究对于高龄初产是否也会影响乳腺癌生存预后呈现出相互矛盾的结果。本研究的目的是探讨初产年龄与乳腺癌诊断后的生存情况之间的关系。
我们使用了马尔默饮食与癌症研究的信息。基线时纳入了17,035名女性。所有女性从患乳腺癌的年份开始随访，直至死亡或随访结束。所有女性被问及生育子女的数量，然后被分为不同组，即≤20岁、>20岁至≤25岁、>25岁至≤30岁以及>30岁。未生育女性单独作为一组。随后使用Cox比例风险生存分析进行生存分析。与参照组≤20岁相比，所有年龄组的女性乳腺癌特异性死亡风险均较低，但差异无统计学意义。与同一参照组相比，未生育女性乳腺癌特异性死亡风险较高，但这些结果无统计学意义。我们未发现初产年龄晚对乳腺癌特异性生存有任何负面影响。
