miR-145 通过调控 NF-κB 通路抑制甲状腺乳头状癌细胞的迁移和侵袭。
MiR-145 inhibits the migration and invasion of papillary thyroid carcinoma cells through NF-κB pathway regulation.
机构信息
The Second Department of General Surgery, The Fourth Hospital of Jinan City, Jinan, Shandong, China.
Department of Laboratory Medicine, Shandong Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.
出版信息
J Cell Biochem. 2020 Jun;121(5-6):3325-3332. doi: 10.1002/jcb.29604. Epub 2020 Jan 7.
Papillary thyroid carcinoma (PTC) is the most prevalent cancer in the endocrine system, and the number of patients diagnosed with PTC has been increasing rapidly in recent years. Previous studies have reported that miR-145 plays an important role in many kinds of cancers, but its function in PTC remains unclear. In this study, we found that compared to paracancerous tissues, the level of miR-145 expression was significantly downregulated in PTC tissues. When miR-145 is overexpressed, migration and invasion of PTC cells were suppressed in vitro. In addition, we found that miR-145 downregulated the nuclear factor-κB (NF-κB) pathway in PTC cells. Taken together, our data suggest that miR-145 functions as a tumor suppressor in PTC with the suppressive effect related to downregulation of the NF-κB pathway.
甲状腺乳头状癌 (PTC) 是内分泌系统最常见的癌症，近年来诊断出的 PTC 患者数量迅速增加。先前的研究报告表明，miR-145 在多种癌症中发挥着重要作用，但它在 PTC 中的功能尚不清楚。在本研究中，我们发现与癌旁组织相比，miR-145 在 PTC 组织中的表达水平显著下调。当 miR-145 过表达时，体外 PTC 细胞的迁移和侵袭受到抑制。此外，我们发现 miR-145 下调了 PTC 细胞中的核因子-κB (NF-κB) 通路。综上所述，我们的数据表明 miR-145 在 PTC 中作为肿瘤抑制因子发挥作用，其抑制作用与 NF-κB 通路的下调有关。
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